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Angiotensin-converting enzyme I/D polymorphism in Behçet's disease

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dc.contributor.author Turgut, Sebahat
dc.contributor.author Turgut, Günfer
dc.contributor.author Atalay, Erol Ömer
dc.contributor.author Atalay, Ayfer
dc.date.accessioned 2019-08-16T11:37:51Z
dc.date.available 2019-08-16T11:37:51Z
dc.date.issued 2005
dc.identifier.issn 10117571 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4838
dc.description.abstract Objective: To investigate a potential relationship between I/D polymorphism within intron 16 of the angiotensin-converting enzyme (ACE) gene located on human chromosome 17 and Behçet's disease. Materials and Methods: Genomic DNA was obtained from 35 Turkish patients diagnosed with Behçet's disease according to the International Study Group criteria and 150 healthy individuals. Polymerase chain reaction was used to detect the presence of I and D (insertion and deletion) alleles in intron 16 of the ACE gene in these DNA samples. Results: We found differences in ACE I/D polymorphism between Behçet's disease and healthy controls (χ2 = 4.61, d.f. = 1, p = 0.044). In Behçet's disease patients, the D allele frequency was 84.3% and I allele frequency 15.7%. Conclusion: An association between Behçet's disease and ACE polymorphism may provide a useful basis for future molecular studies and therapeutic approaches in this complex disease. Copyright © 2005 S. Karger AG.
dc.language.iso English
dc.relation.isversionof 10.1159/000085737
dc.rights info:eu-repo/semantics/openAccess
dc.subject Angiotensin-converting enzyme
dc.subject Angiotensin-converting enzyme I/D polymorphism
dc.subject Behçet's disease
dc.subject dipeptidyl carboxypeptidase
dc.subject genomic DNA
dc.subject allele
dc.subject article
dc.subject Behcet disease
dc.subject chromosome 17
dc.subject clinical article
dc.subject comparative study
dc.subject controlled study
dc.subject DNA determination
dc.subject DNA polymorphism
dc.subject female
dc.subject gene deletion
dc.subject gene frequency
dc.subject gene insertion
dc.subject gene location
dc.subject genetic association
dc.subject human
dc.subject intron
dc.subject male
dc.subject polymerase chain reaction
dc.subject Behcet Syndrome
dc.subject Chromosomes, Human, Pair 17
dc.subject Female
dc.subject Gene Frequency
dc.subject Humans
dc.subject Male
dc.subject Peptidyl-Dipeptidase A
dc.subject Polymerase Chain Reaction
dc.subject Polymorphism, Genetic
dc.subject Turkey
dc.title Angiotensin-converting enzyme I/D polymorphism in Behçet's disease
dc.type Article
dc.relation.journal Medical Principles and Practice
dc.contributor.authorID 0000-0002-7884-5623
dc.identifier.volume 14
dc.identifier.issue 4
dc.identifier.startpage 213
dc.identifier.endpage 216
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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