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QT dispersion and left ventricular hypertrophy in athletes: Relationship with angiotensin-converting enzyme I/D polymorphism

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dc.contributor.author Tanrıverdi, Halil
dc.contributor.author Kaftan, Havane Asuman
dc.contributor.author Evrengül, Harun
dc.contributor.author Dursunoğlu, Dursun
dc.contributor.author Turgut, Günfer
dc.contributor.author Kılıç, Mustafa
dc.date.accessioned 2019-08-16T11:37:40Z
dc.date.available 2019-08-16T11:37:40Z
dc.date.issued 2005
dc.identifier.issn 00015385 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4821
dc.description.abstract Background - QT dispersion (QTd) is a measure of inhomogeneous repolarization of myocardium and is used as an indicator of arrhythmogenicity. QTd is increased in myocardial hypertrophy secondary to systemic hypertension. The relation between left ventricular (LV) enlargement in endurance trained subjects and QTd is unknown. The cloning of the angiotensin-converting enzyme (ACE) gene has made it possible to identify a deletion (D)-insertion (I) polymorphism that appears to affect the level of serum ACE activity. The aim of this study was to assess whether physiologic left ventricular hypertrophy as a result of physical training is associated with an increased QT length or dispersion depending on ACE I/D polymorphism. Methods - 56 endurance athletes and 46 sedentary subjects were included in this study, and they underwent both complete echocardiographic and electrocardiographic examination, the QT interval was measured manually as an average based on a 12-lead ECG. We also analysed ACE I and D allele frequencies in all patients. Results - Athletes had a significantly increased LV mass (235.1 ± 68.5 g vs. 144.9 ± 44.5 g, p < 0.001) and corrected QTd (QTcd) (55.5 ± 18.1 ms vs. 42.9 ± 17.2 ms, p < 0.001) in comparison to control subjects. There was a positive correlation between left ventricular mass index and QTcd in athletes (r = 0.3, p = 0.024). Left ventricular mass and mass index in ACE DD, DI and II genotypes were significantly different (p < 0.001). QTcd was significantly different between ACE DD (63.2 ± 12.8 ms) and ACE II (44.9 ± 17.6 ms) genotypes in athletes (p < 0.05). Conclusion - These data show that myocardial hypertrophy induced by exercise training might be associated with increased QTd as observed in systemic hypertension and might be affected by ACE I/D polymorphism.
dc.language.iso English
dc.relation.isversionof 10.2143/AC.60.4.2004987
dc.rights info:eu-repo/semantics/closedAccess
dc.subject ACE I/D polymorphism
dc.subject Athlete
dc.subject QT dispersion
dc.subject Ventricular hypertrophy
dc.subject dipeptidyl carboxypeptidase
dc.subject DNA
dc.subject adult
dc.subject article
dc.subject athlete
dc.subject controlled study
dc.subject echocardiography
dc.subject electrocardiogram
dc.subject female
dc.subject genetic polymorphism
dc.subject genotype
dc.subject heart left ventricle hypertrophy
dc.subject human
dc.subject major clinical study
dc.subject male
dc.subject training
dc.subject Adult
dc.subject Case-Control Studies
dc.subject Echocardiography
dc.subject Electrocardiography
dc.subject Exercise
dc.subject Female
dc.subject Genotype
dc.subject Heart Ventricles
dc.subject Humans
dc.subject Hypertrophy, Left Ventricular
dc.subject Male
dc.subject Peptidyl-Dipeptidase A
dc.subject Physical Endurance
dc.subject Polymorphism, Genetic
dc.subject Regression Analysis
dc.subject Sports
dc.title QT dispersion and left ventricular hypertrophy in athletes: Relationship with angiotensin-converting enzyme I/D polymorphism
dc.type Article
dc.relation.journal Acta Cardiologica
dc.contributor.authorID 0000-0002-0705-7726
dc.contributor.authorID 0000-0002-5232-7078
dc.identifier.volume 60
dc.identifier.issue 4
dc.identifier.startpage 387
dc.identifier.endpage 393
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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