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Effects of angiotensin-converting enzyme polymorphism on aortic elastic parameters in athletes

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dc.contributor.author Tanriverdi, H.
dc.contributor.author Evrengul, H.
dc.contributor.author Kaftan, A.
dc.contributor.author Dursunoglu, D.
dc.contributor.author Turgut, S.
dc.contributor.author Akdaǧ, B.
dc.contributor.author Kiliç, M.
dc.date.accessioned 2019-08-16T11:37:25Z
dc.date.available 2019-08-16T11:37:25Z
dc.date.issued 2005
dc.identifier.issn 00086312 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4799
dc.description.abstract Background: Physiologic adaptations in an athlete's heart include increased left and right ventricular chamber size, left ventricular wall thickness and mass. Angiotensin-converting enzyme (ACE) is a key enzyme in angiotensin II production causing cardiac hypertrophy. The cloning of the ACE gene has made it possible to identify a deletion (D)-insertion (I) polymorphism that appears to affect the level of serum ACE activity. Therefore, the ACE genes, which have been shown to be polymorphic, could be candidate genes for large-artery stiffness. Methods: 56 endurance athletes and 46 sedentary subjects were included in this study, and they underwent both complete echocardiographic examination, and analysis of ACE insertion (I) and deletion (D) allele frequencies in peripheral blood. The aortic diameter was recorded by M-mode echocardiography at a level 3 cm above the aortic valve. Aortic systolic diameter was measured at the time of full opening of the aortic valve, and diastolic diameter was measured at the peak of QRS. Aortic strain, stiffness index and distensibility were calculated. Results: Left ventricular mass index and left ventricular ejection fraction were significantly higher in athletes than controls (p < 0.001). The aortic distensibility index and strain were significantly greater in athletes compared with controls (respectively: 5.8 ± 2.7 vs. 4.7 ± 1.8 cm-2 dyn-1 10 -6, p = 0.017; 12.3 ± 2.4 vs. 9.3 ± 3.1, p < 0.001). The aortic stiffness index was significantly lower in athletes than in controls (4.8 ± 1.9 vs. 6.1 ± 2.1, p < 0.001). The aortic distensibility index and strain were statistically different in ACE DD vs. DI groups and DD vs. II groups of athletes. The aortic stiffness index was statistically different in ACE DD vs. II groups of athletes. Aortic parameters were similar according to ACE genotypes in controls. Conclusion: The results of this study indicate that aortic distensibility was increased by prolonged training in endurance athletes, particularly in those with the ACE II genotype. This effect represents an extracardiac adaptation to chronic prolonged training in athletes. Copyright © 2005 S. Karger AG.
dc.language.iso English
dc.relation.isversionof 10.1159/000087243
dc.subject Angiotensin-converting enzyme
dc.subject Aortic stiffness
dc.subject Athlete
dc.subject Insertion/deletion polymorphism
dc.subject dipeptidyl carboxypeptidase
dc.subject adult
dc.subject aorta
dc.subject aorta valve
dc.subject artery compliance
dc.subject artery diameter
dc.subject article
dc.subject athlete
dc.subject blood vessel parameters
dc.subject controlled study
dc.subject diastole
dc.subject DNA polymorphism
dc.subject echocardiography
dc.subject enzyme polymorphism
dc.subject female
dc.subject gene deletion
dc.subject gene frequency
dc.subject gene insertion
dc.subject genetic analysis
dc.subject genotype
dc.subject heart left ventricle ejection fraction
dc.subject heart left ventricle volume
dc.subject heart valve
dc.subject human
dc.subject M mode echocardiography
dc.subject male
dc.subject physical stress
dc.subject priority journal
dc.subject QRS complex
dc.subject systole
dc.subject training
dc.subject Adaptation, Physiological
dc.subject Adult
dc.subject Aorta
dc.subject Echocardiography
dc.subject Elasticity
dc.subject Female
dc.subject Genotype
dc.subject Heart Ventricles
dc.subject Humans
dc.subject Hypertrophy, Left Ventricular
dc.subject Male
dc.subject Myocardial Contraction
dc.subject Peptidyl-Dipeptidase A
dc.subject Physical Endurance
dc.subject Polymorphism, Genetic
dc.subject Sports
dc.subject Stroke Volume
dc.subject Ventricular Function, Left
dc.title Effects of angiotensin-converting enzyme polymorphism on aortic elastic parameters in athletes
dc.type Article
dc.relation.journal Cardiology
dc.identifier.volume 104
dc.identifier.issue 3
dc.identifier.startpage 113
dc.identifier.endpage 119
dc.identifier.index Scopus

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