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The effects of tangential radiotherapy on lung clearance in breast cancer patients

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dc.contributor.author Yüksel, Doğangün
dc.contributor.author Sürenkök, S.
dc.contributor.author Ilgan, S.
dc.contributor.author Öztürk, E.
dc.contributor.author Pak, Y.
dc.date.accessioned 2019-08-16T11:36:57Z
dc.date.available 2019-08-16T11:36:57Z
dc.date.issued 2005
dc.identifier.issn 01678140 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4755
dc.description.abstract Purpose: The aim of this study was to investigate the effects of tangential radiotherapy (RT) on lung clearance in the patients with breast cancer by using 99mTc-DTPA aerosol scintigraphy. Material and methods: Thirty-three female patients [non-smoker: 20, ex-smoker: 13] performed surgery and systemic chemotherapy for breast carcinoma [47±13 years] were included in the study. All patients underwent 99mTc-DTPA aerosol scintigraphy prior to RT (preRT), midway through RT (midRT) and after RT (postRT). Total dose was 50 Gy in modified radical mastectomy and 60 Gy in lumpectomy (2 Gy/fraction). Posterior dynamic images of lungs were obtained immediately after the inhalation of 99mTc-DTPA aerosol. Results: Pulmonary function tests were normal in three measurements for all cases. In the ex-smokers, there was no significant difference among preRT, midRT and postRT clearance values in both lungs. PreRT lung clearance in non-smoker group did not differ from that in ex-smokers. However, the lung clearance for non-smoker group showed significantly increase following RT. Conclusion: In this study, we observed that tangential radiotherapy caused an increase in the lung clearance in the cases of non-smokers even in non-irradiated lung, and that the effect of RT on lung clearance was closely depended on smoking habit before RT. © 2005 Elsevier Ireland Ltd. All rights reserved.
dc.language.iso English
dc.relation.isversionof 10.1016/j.radonc.2005.10.013
dc.rights info:eu-repo/semantics/closedAccess
dc.subject 99mTc-DTPA
dc.subject Aerosol scintigraphy
dc.subject Breast cancer
dc.subject Lung clearance
dc.subject Radiation pneumonitis
dc.subject Radiotherapy
dc.subject Smoking habits
dc.subject pentetate technetium tc 99m
dc.subject tamoxifen
dc.subject adult
dc.subject aerosol
dc.subject aged
dc.subject article
dc.subject breast carcinoma
dc.subject cancer chemotherapy
dc.subject cancer radiotherapy
dc.subject clinical article
dc.subject controlled study
dc.subject female
dc.subject human
dc.subject lung clearance
dc.subject lung function test
dc.subject mastoidectomy
dc.subject partial mastectomy
dc.subject priority journal
dc.subject radiation dose distribution
dc.subject radiation dose fractionation
dc.subject radiation exposure
dc.subject radiation response
dc.subject scintimammography
dc.subject smoking
dc.subject tangential radiotherapy
dc.subject Adult
dc.subject Aerosols
dc.subject Antineoplastic Agents, Hormonal
dc.subject Breast Neoplasms
dc.subject Female
dc.subject Humans
dc.subject Lung
dc.subject Mastectomy, Modified Radical
dc.subject Mastectomy, Segmental
dc.subject Middle Aged
dc.subject Radiation Pneumonitis
dc.subject Radiopharmaceuticals
dc.subject Radiotherapy, Adjuvant
dc.subject Radiotherapy, Conformal
dc.subject Respiratory Function Tests
dc.subject Smoking
dc.subject Tamoxifen
dc.subject Technetium Tc 99m Pentetate
dc.title The effects of tangential radiotherapy on lung clearance in breast cancer patients
dc.type Article
dc.relation.journal Radiotherapy and Oncology
dc.contributor.authorID 0000-0003-0983-2834
dc.identifier.volume 77
dc.identifier.issue 3
dc.identifier.startpage 262
dc.identifier.endpage 266
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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