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Effects of CPAP on right ventricular myocardial performance index in obstructive sleep apnea patients without hypertension

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dc.contributor.author Dursunoğlu, Neşe
dc.contributor.author Dursunoğlu, Dursun
dc.contributor.author Özkurt, Sibel
dc.contributor.author Gür, Şükrü
dc.contributor.author Özalp, Güllü
dc.contributor.author Evyapan, Fatma
dc.date.accessioned 2019-08-16T11:36:03Z
dc.date.available 2019-08-16T11:36:03Z
dc.date.issued 2006
dc.identifier.issn 1465993X (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4662
dc.description.abstract Objectives: Obstructive sleep apnoea (OSA) might cause right ventricular dysfunction and pulmonary hypertension. We aimed to determine the effects of nasal continuous positive airway pressure (CPAP) therapy on right ventricular myocardial performance index (MPI) in OSA patients without hypertension. Methods: 49 subjects without hypertension, diabetes mellitus, any cardiac and pulmonary disease had overnight polysomnography and echocardiography. In 18 moderate-severe OSA (apnea-hypopnea index ≥ 15) patients, right ventricular free wall diameter (RVFWD) was measured by M-mode, and right ventricular MPI was calculated as (isovolumic contraction time+ isovolumic relaxation time) / pulmonary ejection time using Doppler at baseline and after 6 months CPAP therapy. Results: Mean age was 46.5 ± 4.9 year. Patients had high body mass index (BMI: 30.6 ± 4,0 kg/m2), but there was no change in either BMI or blood pressures after 6 months. Right ventricular end-diastolic and end-systolic diameters were in normal limits at baseline, and did not change after CPAP usage. Baseline RVFWD (7.1 ± 2.1 mm) significantly decreased after CPAP therapy (6.2 ± 1.7 mm, p < 0.001). 15 of patients (83%) had right ventricular diastolic dysfunction at baseline, and it was completely improved in 11 of them (73%) by CPAP usage. Right ventricular global dysfunction was shown in 11 patients (61%) with a high MPI (62.2 ± 9.3%) at baseline; and MPI was significantly decreased after CPAP therapy (47.3 ± 8.4%, p < 0.0001), and it was completely corrected in 4 of them (36%). Conclusion: CPAP therapy significantly decreases RVFWD and improves right ventricular diastolic and global functions (MPI) in OSA patients without hypertension. © 2006 Dursunoglu et al; licensee BioMed Central Ltd.
dc.language.iso English
dc.relation.isversionof 10.1186/1465-9921-7-22
dc.rights info:eu-repo/semantics/openAccess
dc.subject adult
dc.subject article
dc.subject blood pressure measurement
dc.subject body mass
dc.subject clinical article
dc.subject controlled study
dc.subject diabetes mellitus
dc.subject disease association
dc.subject disease severity
dc.subject Doppler echography
dc.subject female
dc.subject heart contraction
dc.subject heart index
dc.subject heart muscle relaxation
dc.subject heart performance
dc.subject heart right ventricle function
dc.subject heart right ventricle hypertrophy
dc.subject heart ventricle enddiastolic pressure
dc.subject heart ventricle wall
dc.subject human
dc.subject hypertension
dc.subject M mode echocardiography
dc.subject male
dc.subject patient compliance
dc.subject polysomnography
dc.subject positive end expiratory pressure
dc.subject rating scale
dc.subject scoring system
dc.subject sleep apnea syndrome
dc.subject statistical analysis
dc.subject statistical significance
dc.subject blood pressure
dc.subject echocardiography
dc.subject middle aged
dc.subject pathophysiology
dc.subject time
dc.subject Adult
dc.subject Blood Pressure
dc.subject Body Mass Index
dc.subject Continuous Positive Airway Pressure
dc.subject Echocardiography
dc.subject Female
dc.subject Humans
dc.subject Hypertension
dc.subject Male
dc.subject Middle Aged
dc.subject Polysomnography
dc.subject Sleep Apnea, Obstructive
dc.subject Time Factors
dc.subject Ventricular Function, Right
dc.title Effects of CPAP on right ventricular myocardial performance index in obstructive sleep apnea patients without hypertension
dc.type Article
dc.relation.journal Respiratory Research
dc.contributor.authorID 0000-0002-6323-3456
dc.contributor.authorID 0000-0002-5232-7078
dc.contributor.authorID 0000-0003-0800-2177
dc.identifier.volume 7
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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