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The effects of amifostine and dexamethasone on brain tissue lipid peroxidation during oxygen treatment of carbon monoxide - Poisoned rats

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dc.contributor.author Atalay, H.
dc.contributor.author Aybek, H.
dc.contributor.author Koseoglu, M.
dc.contributor.author Demir, S.
dc.contributor.author Erbay, H.
dc.contributor.author Bolaman, A.Z.
dc.contributor.author Avci, A.
dc.date.accessioned 2019-08-16T11:36:01Z
dc.date.available 2019-08-16T11:36:01Z
dc.date.issued 2006
dc.identifier.issn 0741238X (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4660
dc.description.abstract The mechanisms of injury of, and methods of treating patients with, carbon monoxide (CO) poisoning are poorly understood. Besides the hypoxic degenerative effects of CO, reoxygenation injury may play an important role. Amifostine (Ami), which is most often used in radiotherapy for its tissue protective characteristics, may offer benefits. In this study, investigators evaluated the effectiveness of various treatments in a CO-poisoned rat model. A total of 36 Wistar rats were randomly assigned to 1 of 6 groups (n=6 each), including control and poisoned groups exposed to CO at 2000 ppm (v/v) for 1 h, followed by various 1-h treatments: group C (control), group CO-air (ambient air), group CO-NBO (normobaric 100% oxygen), group CO-HBO (hyperbaric oxygen with 3 atmospheres absolute [3 ATA]), group CO-NBO-Ami (normobaric oxygen with intraperitoneal [IP] injection of amifostine 250 mg/kg body weight [bw]), and group CO-70O (70% O 2 and 5% CO 2 with dexamethasone 10 mg/kg bw, IP). Blood gas analysis, carboxyhemoglobin determination, brain tissue lipid peroxidation, and glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), lactate dehydrogenase (LDH), and creatine kinase (CK) activities were evaluated. Carboxyhemoglobin concentration in the air-treated group was 44±2%; it decreased to the control level with all oxygen treatments. Brain tissue GSH-Px and SOD measurements did not change. The activity of LDH in group CO-HBO and the activities of LDH and CK in group CO-70O were similar to those of group C. Lipid peroxides were high in ambient air and normobaric oxygen, but HBO, amifostine with oxygen, or 70% O 2 reduced these to control levels (P<.05). ©2006 Health Communications Inc.
dc.language.iso English
dc.relation.isversionof 10.1007/BF02850138
dc.subject Amifostine
dc.subject Carbon monoxide
dc.subject Hyperbaric
dc.subject Lipid peroxidation
dc.subject Poisoning
dc.subject amifostine
dc.subject carboxyhemoglobin
dc.subject creatine kinase
dc.subject cytochrome c oxidase
dc.subject dexamethasone
dc.subject glutathione peroxidase
dc.subject lactate dehydrogenase
dc.subject lipid peroxide
dc.subject superoxide dismutase
dc.subject ambient air
dc.subject animal experiment
dc.subject animal model
dc.subject apoptosis
dc.subject article
dc.subject blood gas analysis
dc.subject brain tissue
dc.subject carbon monoxide intoxication
dc.subject cell death
dc.subject controlled study
dc.subject drug effect
dc.subject hyperbaric oxygen
dc.subject lipid peroxidation
dc.subject male
dc.subject nonhuman
dc.subject oxidative stress
dc.subject oxygen therapy
dc.subject oxygen transport
dc.subject rat
dc.subject risk benefit analysis
dc.subject tissue oxygenation
dc.subject Animals
dc.subject Brain
dc.subject Brain Injuries
dc.subject Carbon Monoxide Poisoning
dc.subject Creatine Kinase
dc.subject Dexamethasone
dc.subject Disease Models, Animal
dc.subject Hyperbaric Oxygenation
dc.subject L-Lactate Dehydrogenase
dc.subject Lipid Peroxidation
dc.subject Male
dc.subject Rats
dc.subject Rats, Wistar
dc.subject Thiobarbituric Acid Reactive Substances
dc.title The effects of amifostine and dexamethasone on brain tissue lipid peroxidation during oxygen treatment of carbon monoxide - Poisoned rats
dc.type Article
dc.relation.journal Advances in Therapy
dc.identifier.volume 23
dc.identifier.issue 2
dc.identifier.startpage 332
dc.identifier.endpage 341
dc.identifier.index Scopus


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