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The relationship between heart rate recovery and heart rate variability in coronary artery disease

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dc.contributor.author Evrengul, H.
dc.contributor.author Tanrıverdi, Halil
dc.contributor.author Kose, S.
dc.contributor.author Amasyali, B.
dc.contributor.author Kilic, A.
dc.contributor.author Celik, T.
dc.contributor.author Turhan, H.
dc.date.accessioned 2019-08-16T11:35:41Z
dc.date.available 2019-08-16T11:35:41Z
dc.date.issued 2006
dc.identifier.issn 1082720X (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4628
dc.description.abstract Background: Reduced heart rate recovery (HRR) in coronary artery disease (CAD) is predictive of increased cardiovascular mortality and is related to reduced parasympathetic tonus. Objective: To investigate HRR and heart rate variability (HRV) measured at steady state condition and the relationship between these two parameters in CAD. Materials and Methods: In our study, we enrolled 33 (28 males, mean age 52.4 ± 9.6 years) patients with CAD who did not have heart failure, atrial fibrillation, pacemaker, and any disease state that could affect the autonomic functions and 38 age-matched healthy subjects (21 males, mean age 48.3 ± 7.8 years). All the patients underwent submaximal treadmill exercise testing (Bruce protocol). HRR was calculated by subtracting the heart rate values at the 1st, 2nd, and 3rd minutes of the recovery phase from the peak heart rate (HRR1, HRR 2, HRR3). Before exercise testing, short-term steady state HRV analyses of all subjects were obtained with the time- and frequency-domain methods and were correlated to HRR. For frequency-domain analysis, low-frequency HRV (LF, 0.004-0.15 Hz), high-frequency HRV (HF, 0.15-0.5 Hz), and LF/HF ratio were measured for 5 minutes in the morning. For time-domain analysis, standard deviation of the normal-to-normal NN intervals (SDNN), square root of the mean squared differences of successive N-N intervals (RMSSD), and proportion derived by dividing the number of interval differences of successive N-N intervals greater than 50 ms by the total number of N-N intervals (pNN50) were obtained. Only HRR3 was used for the correlation analysis. Results: In CAD groups, the HF, an indicator of parasympathetic activation, was significantly reduced, whereas the LF and LF/HF values, which are indicators of sympathetic activity, were increased (P = 0.0001 for each parameter). The time-domain parameters SDNN, RMSSD, and pNN50 were significantly reduced in the patient group (P = 0.0001, P = 0.009, and P = 0.0001, respectively). Similar to the HRV parameters, the HRR1, HRR2, and HRR3 values were significantly reduced in the patient group (P = 0.0001 for each parameter). We observed a significant negative correlation between HRR3 and LF (r =-0.67, P = 0.0001) and between HRR3 and LF/HF (r =-0.62, P < 0.0001), while there was a significant positive correlation between HRR 3 and HF, SDNN, RMSSD, and pNN50 (r = 0.69, P = 0.0001; r = 0.41, P = 0.0001; r = 0.31, P = 0.008; and r = 0.44, P = 0.0001). Conclusions: HRR and HRV are significantly reduced in CAD. The reduction in HRR is parallel to the changes in HRV parameters. HRR, which can be measured easily in the recovery phase of exercise testing, can be used to detect the depression of parasympathetic tonus and to evaluate the basal autonomic balance in this patient group. ©2006, Copyright the Authors.
dc.language.iso English
dc.relation.isversionof 10.1111/j.1542-474X.2006.00097.x
dc.rights info:eu-repo/semantics/openAccess
dc.subject Coronary artery disease
dc.subject Heart rate recovery
dc.subject Heart rate variability
dc.subject adult
dc.subject article
dc.subject autonomic nervous system
dc.subject calculation
dc.subject cardiovascular parameters
dc.subject cholinergic system
dc.subject clinical article
dc.subject controlled study
dc.subject coronary artery disease
dc.subject correlation analysis
dc.subject evaluation
dc.subject exercise recovery
dc.subject female
dc.subject frequency analysis
dc.subject heart atrium fibrillation
dc.subject heart failure
dc.subject heart rate
dc.subject heart rate variability
dc.subject human
dc.subject male
dc.subject measurement
dc.subject morbidity
dc.subject priority journal
dc.subject prognosis
dc.subject sinus node
dc.subject statistical analysis
dc.subject steady state
dc.subject sympathetic tone
dc.subject treadmill exercise
dc.subject Case-Control Studies
dc.subject Chi-Square Distribution
dc.subject Coronary Arteriosclerosis
dc.subject Exercise Test
dc.subject Female
dc.subject Heart Conduction System
dc.subject Heart Rate
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Predictive Value of Tests
dc.subject Statistics, Nonparametric
dc.title The relationship between heart rate recovery and heart rate variability in coronary artery disease
dc.type Article
dc.relation.journal Annals of Noninvasive Electrocardiology
dc.identifier.volume 11
dc.identifier.issue 2
dc.identifier.startpage 154
dc.identifier.endpage 162
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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