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Prevalence and hematological characteristics of ß-thalassemia trait in Gaziantep urban area, Turkey

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dc.contributor.author Gurbak, M.
dc.contributor.author Sivasli, E.
dc.contributor.author Coskun, Y.
dc.contributor.author Bozkurt, A.
dc.contributor.author Ergin, Ahmet.
dc.date.accessioned 2019-08-16T11:35:09Z
dc.date.available 2019-08-16T11:35:09Z
dc.date.issued 2006
dc.identifier.issn 0888-0018
dc.identifier.uri https://hdl.handle.net/11499/4579
dc.identifier.uri https://doi.org/10.1080/08880010600683400
dc.description.abstract Thalassemia is one of the most common hereditary disorders in the Mediterranean region and studies have shown that the prevalence of ß-thalassemia trait is high in the southern part of Turkey. Gaziantep is a city located near this region and, therefore, the authors investigated the prevalence and hematological characteristics of the ß-thalassemia traits in primary school students in Gaziantep. Sixty primary schools were selected from a list of all primary schools using a systematic sampling method. Data were collected by a face-to-face questionnaire. Osmotic fragility testing (OFT) using single-tube 0.36% NaCl solution was used for the screening of ß-thalassemia. Students who were positive in regard to OFT went through a series of testing, including a complete blood count, serum ferritin levels, serum iron, and hemoglobin electroforesis. Chi-square test was used in statistical analysis. Of the 2439 students enrolled to the study from the selected 60 classrooms, 1353 (55.5%) were male and 1086 (44.5%) were female. The OFT was positive in 115 (4.7%) of the participants. CEA and confirmatory HPLC results of the students who were positive OFT indicated that 70 (60.8%) had normal results, 33(28.7%) showed high HbA2 levels, 7 (6.1%) showed high HbA2 and HbF levels, 5(5.2%) showed high HbA2 and Fe-deficiency anemia, and none showed increased HbF levels. The overall prevalence of ß-thalassemia trait was 1.84%. No gender differentials and highest rates among the Kahramanmaras (3.5%) and Sanliurfa (1.7%) born students were the other significant findings of this study. Implementation of a routine carrier-screening program offering genetic counseling, prenatal diagnosis, and selective termination of affected fetuses would be a wise approach to eliminate this disease from the region. Copyright © Taylor & Francis Group, LLC. en_US
dc.language.iso en en_US
dc.relation.ispartof Pediatric Hematology and Oncology en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject ß-thalassemia trait en_US
dc.subject Gaziantep en_US
dc.subject Prevalence en_US
dc.subject Turkey en_US
dc.subject ferritin en_US
dc.subject hemoglobin en_US
dc.subject hemoglobin A2 en_US
dc.subject hemoglobin F en_US
dc.subject iron en_US
dc.subject article en_US
dc.subject beta thalassemia en_US
dc.subject blood cell count en_US
dc.subject chi square test en_US
dc.subject child en_US
dc.subject electrophoresis en_US
dc.subject female en_US
dc.subject ferritin blood level en_US
dc.subject high performance liquid chromatography en_US
dc.subject human en_US
dc.subject information processing en_US
dc.subject iron blood level en_US
dc.subject iron deficiency anemia en_US
dc.subject male en_US
dc.subject osmotic fragility en_US
dc.subject prevalence en_US
dc.subject primary school en_US
dc.subject questionnaire en_US
dc.subject statistical analysis en_US
dc.subject Adolescent en_US
dc.subject beta-Thalassemia en_US
dc.subject Blood Cell Count en_US
dc.subject Child en_US
dc.subject Female en_US
dc.subject Ferritins en_US
dc.subject Hemoglobins en_US
dc.subject Humans en_US
dc.subject Iron en_US
dc.subject Male en_US
dc.subject Osmotic Fragility en_US
dc.subject Sex Factors en_US
dc.subject Urban Health en_US
dc.title Prevalence and hematological characteristics of ß-thalassemia trait in Gaziantep urban area, Turkey en_US
dc.type Article en_US
dc.identifier.volume 23 en_US
dc.identifier.issue 5 en_US
dc.identifier.startpage 419
dc.identifier.startpage 419 en_US
dc.identifier.endpage 425 en_US
dc.authorid 0000-0001-5236-7507
dc.identifier.doi 10.1080/08880010600683400
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 16728362 en_US
dc.identifier.scopus 2-s2.0-33746806807 en_US
dc.identifier.wos WOS:000237849100006 en_US

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