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Use of total patient data for indirect estimation of reference intervals for 40 clinical chemical analytes in Turkey

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dc.contributor.author Iicol, Y.O.
dc.contributor.author Aslan, Diler.
dc.date.accessioned 2019-08-16T11:34:59Z
dc.date.available 2019-08-16T11:34:59Z
dc.date.issued 2006
dc.identifier.issn 14346621 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4560
dc.description.abstract In the present study we used patient data to calculate laboratory-specific indirect reference intervals. These values were compared with reference intervals obtained for a healthy group according to recommendations of the International Federation of Clinical Chemistry and Laboratory Medicine and manufacturer suggestions. Laboratory results (422,919 records) from all subjects of 18-45 years of age over a 1-year period were retrieved from our laboratory information system and indirect reference intervals for 40 common analytes were estimated using a modified Bhattacharya procedure. Indirect reference intervals for most of the biochemical analytes were comparable, with small differences in lower [alkaline phosphatase (ALP) (male), alanine aminotransferase (ALT), creatine kinase, iron (male), total iron-binding capacity, folic acid, calcium (female), lactate dehydrogenase (LDH), lipoprotein (a) [Lp(a)], thyroid-stimulating hormone (TSH), total triiodothyronine (T3), direct bilirubin, apolipoprotein A-I (apoA-I), glucose, homocysteine, total cholesterol, ferritin, total protein, ceruloplasmin, sodium, blood urea nitrogen (BUN) and uric acid (female)] and/or upper limits [albumin, ALP (male), amylase, apoA-I, creatine kinase-MB (CK-MB), total iron-binding capacity, phosphorus, glucose, total cholesterol, γ-glutamyltransferase (γ-GT), magnesium, total protein, high-density lipoprotein cholesterol (HDL-C), total T3, ALP (male), ALT, aspartate aminotransferase (AST) (male), direct bilirubin (male), creatine kinase, iron, folic acid (female), Lp(a), uric acid and triglycerides], to the reference intervals determined for healthy subjects in our laboratory. The indirect reference intervals, with the exception of a few parameters (creatinine, direct total bilirubin, calcium, BUN and potassium), were not similar to the reference intervals suggested by the manufacturers. We conclude that laboratory-specific reference intervals can be determined from stored data with a relatively easy and inexpensive method. Indirect reference intervals derived from stored data may be particularly suitable for the evaluation of results for the presenting population. © 2006 by Walter de Gruyter.
dc.language.iso English
dc.relation.isversionof 10.1515/CCLM.2006.139
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Biochemical analytes
dc.subject Healthy subjects
dc.subject Indirect reference intervals
dc.subject Manufacturer suggestions
dc.subject Modified Bhattacharya procedure
dc.subject Patient data
dc.subject Turkish population
dc.subject alanine aminotransferase
dc.subject albumin
dc.subject alkaline phosphatase
dc.subject amylase
dc.subject apolipoprotein A1
dc.subject apolipoprotein B
dc.subject aspartate aminotransferase
dc.subject bilirubin
dc.subject calcium
dc.subject ceruloplasmin
dc.subject chloride
dc.subject cholesterol
dc.subject creatine kinase
dc.subject creatine kinase MB
dc.subject creatinine
dc.subject ferritin
dc.subject folic acid
dc.subject gamma glutamyltransferase
dc.subject glucose
dc.subject high density lipoprotein cholesterol
dc.subject homocysteine
dc.subject lactate dehydrogenase
dc.subject liothyronine
dc.subject lipoprotein A
dc.subject magnesium
dc.subject phosphorus
dc.subject potassium
dc.subject protein
dc.subject sodium
dc.subject thyroxine
dc.subject adult
dc.subject albumin blood level
dc.subject alkaline phosphatase blood level
dc.subject amylase blood level
dc.subject analytic method
dc.subject article
dc.subject aspartate aminotransferase blood level
dc.subject bilirubin blood level
dc.subject blood chemistry
dc.subject calcium blood level
dc.subject ceruloplasmin blood level
dc.subject chemoluminescence
dc.subject chloride blood level
dc.subject cholesterol blood level
dc.subject colorimetry
dc.subject creatine kinase blood level
dc.subject creatinine blood level
dc.subject enzyme blood level
dc.subject female
dc.subject ferritin blood level
dc.subject fluorescence polarization immunoassay
dc.subject folic acid blood level
dc.subject gamma glutamyl transferase blood level
dc.subject glucose blood level
dc.subject human
dc.subject immunoassay
dc.subject intermethod comparison
dc.subject iron blood level
dc.subject laboratory test
dc.subject liothyronine blood level
dc.subject lipoprotein blood level
dc.subject magnesium blood level
dc.subject major clinical study
dc.subject male
dc.subject medical instrumentation
dc.subject microparticle enzyme immunoassay
dc.subject patient information
dc.subject phosphate blood level
dc.subject potassium blood level
dc.subject priority journal
dc.subject protein blood level
dc.subject quality control
dc.subject reference value
dc.subject sodium blood level
dc.subject thyrotropin blood level
dc.subject thyroxine blood level
dc.subject transferrin blood level
dc.subject triacylglycerol blood level
dc.subject Turkey (republic)
dc.subject urea blood level
dc.subject uric acid blood level
dc.subject Adolescent
dc.subject Adult
dc.subject Chemistry, Clinical
dc.subject Clinical Chemistry Tests
dc.subject Female
dc.subject Health
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Reference Values
dc.subject Turkey
dc.title Use of total patient data for indirect estimation of reference intervals for 40 clinical chemical analytes in Turkey
dc.type Article
dc.relation.journal Clinical Chemistry and Laboratory Medicine
dc.identifier.volume 44
dc.identifier.issue 7
dc.identifier.startpage 867
dc.identifier.endpage 876
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS


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