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The effects of treatment with Saccharomyces boulardii on bacterial translocation in rats with obstructive jaundice

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dc.contributor.author Herek, Özkan.
dc.contributor.author Yılmaz, Mustafa.
dc.contributor.author Kaleli, İlknur.
dc.contributor.author Cevahir, Nural.
dc.date.accessioned 2019-08-16T11:34:54Z
dc.date.available 2019-08-16T11:34:54Z
dc.date.issued 2006
dc.identifier.issn 13055194 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4552
dc.description.abstract Aim: The aim of this study was to evaluate the effects of the treatment with Saccharomyces boluardii which is widely used as a probiotic on bacterial translocation (BT) in biliary obstruction. Material and Methods: For this purpose, thirty male albino rats were, divided in 3 groups: Group 1. Sham-operated (n = 10), Group 2. Common bile duct (CBD)-ligated (n = 10), Group 3. Common bile duct-ligated and treated with Saccharomyces boluardii (n=10). In group 3, rats were treated with Saccharomyces holuardii (1mg/g body weight/clay) that was given by orogastric feeding tube for five days after CBD ligation. In Group 1 and Group 2, rats were given same amounts of sterile saline as placebo. After 6 days of surgery, all rats were sacrificed. Cultures of the mesenteric lymph nodes (MLNs), liver, spleen, blood and cccal contents were obtained. Results: The incidence of bacterial translocation was found as 10 % in Group 1,70 % in Group 2 and, 30 % in Group 3. Increase in the incidence of bacterial translocation was statistically significant in Group 2 compared with Group 1 (p<0.05). Although the incidence of bacterial traslocation in Group 3 was not statistically significant compared with Group 2 (p>0.05), a significant increase was not found compared with Group 1. On the other hand, total bacterial count of cecal flora was found as significantly increased in Group 2 when compared with Group 1 (p<0.01), while there was no statistically significant increase in the total bacterial count of cecal content in group 3 when compared with Group 1 (p>0.05). Conclusion: These data suggested that biliary obstruction promotes and enhances the BT. Saccharomyces boulardii relatively protected the intestinal ecological equilibrium. The administration of S. boulardii may decrease the incidence of BT in obstructive jaundice.
dc.language.iso Turkish
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Bacterial translocation
dc.subject Biliary obstruction
dc.subject Obstructive jaundice
dc.subject Probiotic
dc.subject Saccharomyces boulardii
dc.subject placebo
dc.subject probiotic agent
dc.subject sodium chloride
dc.subject animal experiment
dc.subject animal model
dc.subject article
dc.subject bacterial translocation
dc.subject common bile duct
dc.subject controlled study
dc.subject male
dc.subject mesentery lymph node
dc.subject nonhuman
dc.subject obstructive jaundice
dc.subject rat
dc.title The effects of treatment with Saccharomyces boulardii on bacterial translocation in rats with obstructive jaundice
dc.type Article
dc.relation.journal Cocuk Cerrahisi Dergisi
dc.identifier.volume 20
dc.identifier.issue 1
dc.identifier.startpage 6
dc.identifier.endpage 10
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus

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