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Surface plasmon resonance-based molecular detection of Hb S [ß6(A3)Glu›Val, GAG›GTG] at the gene level

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dc.contributor.author Atalay, Erol Ömer
dc.contributor.author Üstel, E.
dc.contributor.author Yildiz, S.
dc.contributor.author Atalay, Ayfer
dc.date.accessioned 2019-08-16T11:34:37Z
dc.date.available 2019-08-16T11:34:37Z
dc.date.issued 2006
dc.identifier.issn 0363-0269
dc.identifier.uri https://hdl.handle.net/11499/4518
dc.identifier.uri https://doi.org/10.1080/03630260600755807
dc.description.abstract The surface plasmon resonance (SPR) approach, being a relatively novel biophysical method, is used to detect many different targets by biomolecular interaction. The SPR system uses optical and evanescent wave phenomenon. This approach does not need any labels, such as enzymes or isotopes, and the monitored interactions are in real time. In DNA-DNA interaction, the SPR approach is Tm-independent. Here we report our preliminary results for the molecular detection of the Hb S (G A G ›G T G) mutation at codon 6 of the human ß-globin gene. Our preliminary results show that the SPR approach could be applied as an inexpensive and fast routine test system for the molecular diagnosis of abnormal hemoglobins (Hbs), especially in premarital screening programs. Copyright © Taylor & Francis Group, LLC. en_US
dc.language.iso en en_US
dc.relation.ispartof Hemoglobin en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Abnormal hemoglobin (Hb) en_US
dc.subject Hb S en_US
dc.subject Mutation detection en_US
dc.subject Surface plasmon resonance (SPR) en_US
dc.subject adenine en_US
dc.subject glutamic acid en_US
dc.subject guanine en_US
dc.subject hemoglobin S en_US
dc.subject hemoglobin variant en_US
dc.subject thymine en_US
dc.subject valine en_US
dc.subject article en_US
dc.subject codon en_US
dc.subject controlled study en_US
dc.subject cost en_US
dc.subject diagnostic value en_US
dc.subject genetic analysis en_US
dc.subject globin gene en_US
dc.subject hemoglobinopathy en_US
dc.subject human en_US
dc.subject human genetics en_US
dc.subject medical examination en_US
dc.subject mutational analysis en_US
dc.subject screening test en_US
dc.subject surface plasmon resonance en_US
dc.subject Genetic Counseling en_US
dc.subject Globins en_US
dc.subject Hemoglobin, Sickle en_US
dc.subject Humans en_US
dc.subject Point Mutation en_US
dc.subject Premarital Examinations en_US
dc.subject Surface Plasmon Resonance en_US
dc.title Surface plasmon resonance-based molecular detection of Hb S [ß6(A3)Glu›Val, GAG›GTG] at the gene level en_US
dc.type Article en_US
dc.identifier.volume 30 en_US
dc.identifier.issue 3 en_US
dc.identifier.startpage 385
dc.identifier.startpage 385 en_US
dc.identifier.endpage 391 en_US
dc.authorid 0000-0001-6272-9380
dc.authorid 0000-0001-7987-9078
dc.identifier.doi 10.1080/03630260600755807
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 16840230 en_US
dc.identifier.scopus 2-s2.0-33746267905 en_US
dc.identifier.wos WOS:000239075000006 en_US

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