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Elevation of serum and urinary carbohydrate antigen 19-9 in benign hydronephrosis

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dc.contributor.author Aybek, Hülya.
dc.contributor.author Aybek, Zafer.
dc.contributor.author Sınık, Zafer.
dc.contributor.author Demir, Süleyman.
dc.contributor.author Sancak, Burak.
dc.contributor.author Tuncay, Levent.
dc.date.accessioned 2019-08-16T11:34:21Z
dc.date.available 2019-08-16T11:34:21Z
dc.date.issued 2006
dc.identifier.issn 0919-8172
dc.identifier.uri https://hdl.handle.net/11499/4480
dc.identifier.uri https://doi.org/10.1111/j.1442-2042.2006.01593.x
dc.description.abstract Objective: The aim of this study was to find out the predictive role of serum and urinary carbohydrate antigen 19-9 levels in benign hydronephrosis and whether these levels are helpful for differentiation of complete or partial urinary obstruction. Materials and methods: Fifty-four patients with, and 23 without, benign hydronephrosis were enrolled in this study. Serum and urinary carbohydrate antigen 19-9 were determined by the chemiluminescence enzyme immunometric assay method and these levels were correlated with clinical factors. Results: The mean serum (P < 0.0001) and urinary (P < 0.0001) carbohydrate antigen 19-9 and serum creatinine (P < 0.008) levels were significantly higher in the hydronephrosis group than the control group. There was significant correlation between serum and urinary carbohydrate antigen 19-9 levels in the hydronephrosis group (r = 0.639, P < 0.0001). In the hydronephrosis group, there were no significant differences between the serum creatinine, serum or urinary carbohydrate antigen 19-9 levels and the clinical features except symptom duration. The best cut-off value for the serum and urinary carbohydrate antigen 19-9 were found to be 4.84 U/mL and 29.35 U/mL, respectively. Conclusion: Serum and urinary carbohydrate antigen 19-9 levels correlated with each other, were significantly elevated in patients with hydronephrosis and did not predict complete urinary obstruction. Benign hydronephrosis should be considered in the differential diagnosis of carbohydrate antigen 19-9 increments, as this is what is of most importance in clinical practice. © 2006 Japanese Urological Association. en_US
dc.language.iso en en_US
dc.relation.ispartof International Journal of Urology en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject CA 19-9 en_US
dc.subject Hydronephrosis en_US
dc.subject Tumor markers en_US
dc.subject Urine en_US
dc.subject CA 19-9 antigen en_US
dc.subject creatinine en_US
dc.subject adult en_US
dc.subject aged en_US
dc.subject article en_US
dc.subject chemoluminescence en_US
dc.subject controlled study en_US
dc.subject creatinine blood level en_US
dc.subject disease duration en_US
dc.subject enzyme immunoassay en_US
dc.subject female en_US
dc.subject human en_US
dc.subject hydronephrosis en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject priority journal en_US
dc.subject receiver operating characteristic en_US
dc.subject urinary tract obstruction en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject CA-19-9 Antigen en_US
dc.subject Creatinine en_US
dc.subject Diagnosis, Differential en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Linear Models en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Predictive Value of Tests en_US
dc.subject Urologic Diseases en_US
dc.title Elevation of serum and urinary carbohydrate antigen 19-9 in benign hydronephrosis en_US
dc.type Article en_US
dc.identifier.volume 13 en_US
dc.identifier.issue 11 en_US
dc.identifier.startpage 1380
dc.identifier.startpage 1380 en_US
dc.identifier.endpage 1384 en_US
dc.authorid 0000-0003-4154-2052
dc.authorid 0000-0002-0635-4251
dc.authorid 0000-0003-4156-4040
dc.authorid 0000000346316337
dc.identifier.doi 10.1111/j.1442-2042.2006.01593.x
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 17083387 en_US
dc.identifier.scopus 2-s2.0-33750431881 en_US
dc.identifier.wos WOS:000241625000004 en_US

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