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Aortic stiffness, flow-mediated dilatation and carotid intima-media thickness in obstructive sleep apnea: Non-invasive indicators of atherosclerosis

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dc.contributor.author Tanrıverdi, Halil.
dc.contributor.author Evrengül, Harun.
dc.contributor.author Kara, Cüneyt Orhan.
dc.contributor.author Kuru, Ömür.
dc.contributor.author Tanrıverdi, Seyhan.
dc.contributor.author Pekcan, Sibel.
dc.contributor.author Kaftan, Havane Asuman.
dc.contributor.author Kılıç, Mustafa.
dc.date.accessioned 2019-08-16T11:34:19Z
dc.date.available 2019-08-16T11:34:19Z
dc.date.issued 2006
dc.identifier.issn 00257931 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4474
dc.description.abstract Background and Objective: Obstructive sleep apnea (OSA) has a critical association with cardiovascular mortality and morbidity. Carotid intima-media thickness (IMT), flow-mediated dilatation (FMD) and aortic stiffness are early signs of atherosclerosis. The presence of subclinical atherosclerosis was assessed in OSA patients using these parameters. Methods: 40 patients with OSA showing an apnea-hypopnea index (AHI) ≥5 (mean age 51.3 ± 9 years, 32 males) and 24 controls (AHI < 5, mean age 51.9 ± 5.2 years, 19 males) were enrolled in the study. In all subjects, polysomnographic examination and recordings were performed during sleep. IMT of the carotid artery, endothelium-dependent/-independent vasodilation of the brachial artery and aortic elastic parameters were investigated using high-resolution Doppler echocardiography. Results: The demographic data of the patients with OSA and controls were not significantly different. Subjects with OSA demonstrated higher values of aortic stiffness (7.1 ± 1.88 vs. 6.42 ± 1.56, respectively) and IMT (0.85 ± 0.13 vs. 0.63 ± 0.11 mm, p = 0.0001, respectively) but lower distensibility (9.47 ± 1.33 vs. 11.8 ± 3.36 cm2/dyn/106) and FMD (4.57 ± 1.3 vs. 6.34 ± 0.83%, p = 0.0001, respectively) than the controls. The respiratory disturbance index correlated positively with aortic stiffness and IMT and negatively with distensibility and FMD. Conclusion: We observed blunted endothelium-dependent dilatation, increased carotid IMT and aortic stiffness in patients with OSA compared with matched control subjects. This is evident in the absence of other diseases, suggesting that OSA is an independent cause of atherosclerosis. These simple and non-invasive methods help to detect subclinical atherosclerosis in OSA. Copyright © 2006 S. Karger AG.
dc.language.iso English
dc.relation.isversionof 10.1159/000093531
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Aortic elastic properties
dc.subject Carotid artery
dc.subject Endothelial function
dc.subject Flow-mediated dilatation
dc.subject Intima-media thickness
dc.subject Obstructive sleep apnea
dc.subject adult
dc.subject aorta
dc.subject artery blood flow
dc.subject article
dc.subject atherosclerosis
dc.subject carotid artery
dc.subject clinical article
dc.subject controlled study
dc.subject Doppler echocardiography
dc.subject female
dc.subject human
dc.subject intima
dc.subject male
dc.subject polysomnography
dc.subject priority journal
dc.subject sleep apnea syndrome
dc.subject sleep disordered breathing
dc.subject thickness
dc.subject tunica media
dc.subject vasodilatation
dc.subject Aorta, Thoracic
dc.subject Blood Flow Velocity
dc.subject Brachial Artery
dc.subject Carotid Artery, Common
dc.subject Echocardiography
dc.subject Elasticity
dc.subject Female
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Observer Variation
dc.subject Retrospective Studies
dc.subject Severity of Illness Index
dc.subject Sleep Apnea, Obstructive
dc.subject Tunica Intima
dc.subject Ultrasonography, Doppler
dc.subject Vasodilation
dc.title Aortic stiffness, flow-mediated dilatation and carotid intima-media thickness in obstructive sleep apnea: Non-invasive indicators of atherosclerosis
dc.type Article
dc.relation.journal Respiration
dc.contributor.authorID 0000-0003-2219-4283
dc.contributor.authorID 0000-0003-0800-2177
dc.identifier.volume 73
dc.identifier.issue 6
dc.identifier.startpage 741
dc.identifier.endpage 750
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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