Amelioration of aluminium-induced liver damage by vitamin E

Kutlubay, Recep; Oğuz, Emin O.; Abban, Gülçin; Turgut, Sebahat

dc.contributor.author	Kutlubay, Recep
dc.contributor.author	Oğuz, Emin O.
dc.contributor.author	Abban, Gülçin
dc.contributor.author	Turgut, Sebahat
dc.date.accessioned	2019-08-16T11:33:29Z
dc.date.available	2019-08-16T11:33:29Z
dc.date.issued	2007
dc.identifier.issn	03795284 (ISSN)
dc.identifier.uri	http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4335
dc.description.abstract	Objective: To investigate the effects of aluminium sulphate on the microscopic morphology of the liver and on vitamin E amelioration of aluminium-induced liver damage. Methods: Rats were injected intraperitonally with aluminium sulphate alone or aluminium sulphate together with vitamin E, with saline injected rats used as the control group. The study took place in Pamukkale University Faculty of Medicine in 2005. Results: The rats exposed to aluminium showed morphological changes in addition to previously reported biochemical changes in the liver. Ihe anti-oxidant vitamin E significantly diminished the liver damage seen due to aluminium. Conclusion: There is an apparent protective effect of vitamin E on parenteral aluminium exposure.
dc.language.iso	English
dc.rights	info:eu-repo/semantics/openAccess
dc.subject	alpha tocopherol
dc.subject	aluminum sulfate
dc.subject	antioxidant
dc.subject	sodium chloride
dc.subject	animal experiment
dc.subject	animal model
dc.subject	animal tissue
dc.subject	article
dc.subject	biochemistry
dc.subject	cell structure
dc.subject	controlled study
dc.subject	cytoplasm
dc.subject	dietary intake
dc.subject	histopathology
dc.subject	liver cell
dc.subject	liver injury
dc.subject	liver sinusoid
dc.subject	male
dc.subject	microscopy
dc.subject	nonhuman
dc.subject	oxidative stress
dc.subject	randomization
dc.subject	rat
dc.subject	Alum Compounds
dc.subject	Animals
dc.subject	Biopsy, Needle
dc.subject	Dietary Supplements
dc.subject	Disease Models, Animal
dc.subject	Drug Interactions
dc.subject	Immunohistochemistry
dc.subject	Injections, Intraperitoneal
dc.subject	Liver
dc.subject	Liver Diseases
dc.subject	Male
dc.subject	Oxidative Stress
dc.subject	Random Allocation
dc.subject	Rats
dc.subject	Rats, Wistar
dc.subject	Reference Values
dc.subject	Sensitivity and Specificity
dc.subject	Vitamin E
dc.title	Amelioration of aluminium-induced liver damage by vitamin E
dc.type	Article
dc.relation.journal	Saudi Medical Journal
dc.contributor.authorID	0000-0002-7884-5623
dc.identifier.volume	28
dc.identifier.issue	2
dc.identifier.startpage	197
dc.identifier.endpage	200
dc.relation.publicationCategory	Uluslararası Hakemli Dergi
dc.identifier.index	Scopus
dc.identifier.index	WOS