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Amelioration of aluminium-induced liver damage by vitamin E

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dc.contributor.author Kutlubay, Recep
dc.contributor.author Oğuz, Emin O.
dc.contributor.author Abban, Gülçin
dc.contributor.author Turgut, Sebahat
dc.date.accessioned 2019-08-16T11:33:29Z
dc.date.available 2019-08-16T11:33:29Z
dc.date.issued 2007
dc.identifier.issn 03795284 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4335
dc.description.abstract Objective: To investigate the effects of aluminium sulphate on the microscopic morphology of the liver and on vitamin E amelioration of aluminium-induced liver damage. Methods: Rats were injected intraperitonally with aluminium sulphate alone or aluminium sulphate together with vitamin E, with saline injected rats used as the control group. The study took place in Pamukkale University Faculty of Medicine in 2005. Results: The rats exposed to aluminium showed morphological changes in addition to previously reported biochemical changes in the liver. Ihe anti-oxidant vitamin E significantly diminished the liver damage seen due to aluminium. Conclusion: There is an apparent protective effect of vitamin E on parenteral aluminium exposure.
dc.language.iso English
dc.rights info:eu-repo/semantics/openAccess
dc.subject alpha tocopherol
dc.subject aluminum sulfate
dc.subject antioxidant
dc.subject sodium chloride
dc.subject animal experiment
dc.subject animal model
dc.subject animal tissue
dc.subject article
dc.subject biochemistry
dc.subject cell structure
dc.subject controlled study
dc.subject cytoplasm
dc.subject dietary intake
dc.subject histopathology
dc.subject liver cell
dc.subject liver injury
dc.subject liver sinusoid
dc.subject male
dc.subject microscopy
dc.subject nonhuman
dc.subject oxidative stress
dc.subject randomization
dc.subject rat
dc.subject Alum Compounds
dc.subject Animals
dc.subject Biopsy, Needle
dc.subject Dietary Supplements
dc.subject Disease Models, Animal
dc.subject Drug Interactions
dc.subject Immunohistochemistry
dc.subject Injections, Intraperitoneal
dc.subject Liver
dc.subject Liver Diseases
dc.subject Male
dc.subject Oxidative Stress
dc.subject Random Allocation
dc.subject Rats
dc.subject Rats, Wistar
dc.subject Reference Values
dc.subject Sensitivity and Specificity
dc.subject Vitamin E
dc.title Amelioration of aluminium-induced liver damage by vitamin E
dc.type Article
dc.relation.journal Saudi Medical Journal
dc.contributor.authorID 0000-0002-7884-5623
dc.identifier.volume 28
dc.identifier.issue 2
dc.identifier.startpage 197
dc.identifier.endpage 200
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS


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