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The effect of prior biopsy scheme on prostate cancer detection for repeat biopsy population: Results of the 14-core prostate biopsy technique

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dc.contributor.author Eskicorapci, S.Y.
dc.contributor.author Guliyev, F.
dc.contributor.author Islamoglu, E.
dc.contributor.author Ergen, A.
dc.contributor.author Ozen, H.
dc.date.accessioned 2019-08-16T11:33:20Z
dc.date.available 2019-08-16T11:33:20Z
dc.date.issued 2007
dc.identifier.issn 03011623 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4311
dc.description.abstract Objectives: To evaluate the diagnostic performance of 14-core repeat biopsy protocol and the impact of prior biopsy scheme on repeat prostate biopsy group. Methods: 211 patients had repeat biopsy using 14-core protocol consisting of 10-core peripheral zone (classical sextant+4 lateral peripheral cores) and 4-core transitional zone (TZ) biopsies. The diagnostic yield was determined both in patients who had previously undergone sextant or 10-core biopsy protocol. Results: Overall cancer detection rate was 25.6%. 14-core biopsy technique detected cancer in 36.1 and 18.7% of the patients who had a previous sextant biopsy and 10-core biopsy protocol, respectively (P = 0.005). Patients with and without high-grade prostatic intraepithelial neoplasia (HGPIN) in the previous sextant biopsy had 56.5 and 28.3% cancer detection rates on the subsequent extended biopsy, respectively (P = 0.017) Patients who had previous 10-core biopsy with and without HGPIN revealed 22.9 and 17.2% cancer detection rates, respectively (P = 0.465) Additional four lateral peripheral cores detected 33% (3/30) and 17% (4/24) of cancers in patients with previous sextant and 10-core biopsy, respectively. 3.7% of the patients had tumor only in the TZ and none of them had prior extended biopsy. Conclusions: The yield of extended 14-core repeat biopsy protocol was higher in patients with previous negative sextant biopsy compared to the patients with previous negative 10-core biopsy. HGPIN history found on previous sextant biopsy was a strong cancer predictor on repeat biopsy; same was not true for the patients with previous 10-core biopsy. The yield of lateral peripheral cores and TZ biopsies were lower in patients with prior negative extended biopsy. © Springer Science+Business Media B.V. 2006.
dc.language.iso English
dc.relation.isversionof 10.1007/s11255-006-9009-5
dc.subject Diagnosis
dc.subject Prostate biopsy
dc.subject Prostate cancer
dc.subject Prostatic intraepithelial neoplasia
dc.subject adult
dc.subject aged
dc.subject article
dc.subject cancer diagnosis
dc.subject cancer grading
dc.subject cancer patient
dc.subject controlled study
dc.subject human
dc.subject major clinical study
dc.subject male
dc.subject population research
dc.subject prediction
dc.subject prostate biopsy
dc.subject prostate cancer
dc.subject prostatic intraepithelial neoplasia
dc.subject statistical analysis
dc.subject Aged
dc.subject Biopsy
dc.subject Humans
dc.subject Male
dc.subject Middle Aged
dc.subject Prostate
dc.subject Prostatic Intraepithelial Neoplasia
dc.subject Prostatic Neoplasms
dc.subject Risk Factors
dc.title The effect of prior biopsy scheme on prostate cancer detection for repeat biopsy population: Results of the 14-core prostate biopsy technique
dc.type Article
dc.relation.journal International Urology and Nephrology
dc.identifier.volume 39
dc.identifier.issue 1
dc.identifier.startpage 189
dc.identifier.endpage 195
dc.identifier.index Scopus

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