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Allelic frequency of the MCP-1 promoter - 2518 polymorphism in the Turkish population and in Turkish patients with juvenile rheumatoid arthritis

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dc.contributor.author Özyürek, A.R.
dc.contributor.author Gürses, Dolunay.
dc.contributor.author Ülger, Z.
dc.contributor.author Levent, E.
dc.contributor.author Bakiler, A.R.
dc.contributor.author Berdeli, A.
dc.date.accessioned 2019-08-16T11:33:11Z
dc.date.available 2019-08-16T11:33:11Z
dc.date.issued 2007
dc.identifier.issn 07703198 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/4281
dc.description.abstract Although genetic and environmental factors contribute to the pathogenesis of juvenile rheumathoid arthritis (JRA), the etiology and pathogenesis remain controversial. The objective of this study was to investigate genotypic and allelic frequencies of monocyte chemoattractant protein-1 (MCP-1) gene -2518 (G/A) polymorphism in the healthy Turkish population and patients with JRA. Genomic DNA was collected from 66 JRA patients and 150 healthy individuals. To evaluate the association of the -2518 (G/A) MCP-1 gene polymorphism with the outcome of JRA, we analyzed the types of JRA and the score on the childhood health assessment questionnaire (C-HAQ score). In the healthy Turkish population, the frequencies of A and G alleles were 71 and 29%, respectively. No significant difference was observed between the JRA patients and healthy subjects in the distribution allelic and genotypic frequencies of the -2518 (G/A) MCP-1 gene polymorphism (p>0.05). However, the AG genotype was found to be higher and the AA genotype was found to be lower in the patients with systemic type JRA compared to those with the other types of JRA (p=0.019). When the JRA patients were evaluated according to the C-HAQ score, we found that the -2518 (G/A) MCP-1 gene polymorphism did not relate the prognosis (p>0.05). AG genotype was found to be higher in the systemic type of JRA. The results indicate that MCP-1 gene polymorphism might slightly associate with patients with systemic JRA. Further studies are needed to elucidate the role of this polymorphism in the pathogenesis of JRA in various populations because this polymorphism has a functional significance and an ethnic difference. © Clinical Rheumatology 2006.
dc.language.iso English
dc.relation.isversionof 10.1007/s10067-006-0347-6
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Genetic polymorphisms
dc.subject Juvenilerheumathoid arthritis
dc.subject MCP-1
dc.subject Monocytechemoattractant protein-1 gene polymorphism
dc.subject adenine
dc.subject genomic DNA
dc.subject guanine
dc.subject monocyte chemotactic protein 1
dc.subject adolescent
dc.subject article
dc.subject child
dc.subject child health
dc.subject controlled study
dc.subject disease classification
dc.subject DNA isolation
dc.subject environmental factor
dc.subject ethnic difference
dc.subject female
dc.subject gene frequency
dc.subject genetic association
dc.subject genetic polymorphism
dc.subject genotype
dc.subject heredity
dc.subject human
dc.subject human cell
dc.subject juvenile rheumatoid arthritis
dc.subject major clinical study
dc.subject male
dc.subject medical assessment
dc.subject medical research
dc.subject pathogenesis
dc.subject polymerase chain reaction
dc.subject population genetics
dc.subject priority journal
dc.subject prognosis
dc.subject promoter region
dc.subject questionnaire
dc.subject scoring system
dc.subject Turkey (republic)
dc.subject Adolescent
dc.subject Arthritis, Juvenile Rheumatoid
dc.subject Chemokine CCL2
dc.subject Child
dc.subject Child, Preschool
dc.subject Female
dc.subject Gene Frequency
dc.subject Genotype
dc.subject Humans
dc.subject Infant
dc.subject Male
dc.subject Polymorphism, Single Nucleotide
dc.subject Promoter Regions (Genetics)
dc.subject Turkey
dc.title Allelic frequency of the MCP-1 promoter - 2518 polymorphism in the Turkish population and in Turkish patients with juvenile rheumatoid arthritis
dc.type Article
dc.relation.journal Clinical Rheumatology
dc.identifier.volume 26
dc.identifier.issue 4
dc.identifier.startpage 546
dc.identifier.endpage 550
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS

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