DSpace Repository

Effect of homocysteine-induced oxidative stress on endothelial function in coronary slow-flow

Show simple item record

dc.contributor.author Tanriverdi, Halil.
dc.contributor.author Evrengül, Harun.
dc.contributor.author Enli, Yaşar.
dc.contributor.author Kuru, Ömür.
dc.contributor.author Seleci, Deniz.
dc.contributor.author Tanrıverdi, Seyhan.
dc.contributor.author Tüzün, Nurullah.
dc.date.accessioned 2019-08-16T11:33:02Z
dc.date.available 2019-08-16T11:33:02Z
dc.date.issued 2007
dc.identifier.issn 0008-6312
dc.identifier.uri https://hdl.handle.net/11499/4256
dc.identifier.uri https://doi.org/10.1159/000099068
dc.description.abstract Background and Objective: Coronary slow-flow (CSF) phenomenon is characterized by delayed opacification of vessels in a normal coronary angiogram, but its etiopathogenesis remains unclear. Plasma homocysteine (Hcy) level can severely disturb vascular endothelial function and may play a role in the pathogenesis of CSF. In our study, endothelial function in patients with CSF and their relationship with Hcy and oxidative stress parameters are investigated. Method: Forty-four patients with angiographically proven CSF and 44 cases with normal coronary flow pattern with similar risk profile were enrolled in the study. Coronary flow patterns of the cases are determined by Thrombolysis in Myocardial Infarction (TIMI) frame count method. Endothelium dependent flow mediated dilatation (FMD) and independent vasodilatation characteristics are evaluated by high frequency ultrasound over the brachial artery. Superoxide dismutase (SOD) and reduced glutathione (GSH) and reduction of oxidative material in the body and the end product of lipid peroxidation, malondialdehyde (MDA) are measured as oxidative stress markers in blood samples. Results: Plasma Hcy level (µmol/l) of patients with CSF was found to be significantly higher than in controls (12.2 ± 4.9 vs. 8.5 ± 2.8, p = 0.0001). FMD was 7.87 ± 2.0% in controls and 4.98 ± 1.1% in patients with CSF (p = 0.0001). GSH was reduced in patients with CSF. SOD and MDA activity were found higher in patients with CSF than control subjects. Plasma Hcy level was significantly positively correlated with mean TIMI frame count and negatively correlated with FMD in correlation analysis (r = 0.58, p = 0.0001; r = -0.41, p = 0.022; respectively). Conclusion: The present findings allow us to conclude that patients with CSF have increased levels of Hcy and oxidative stress markers and impaired endothelial cell function. Copyright © 2007 S. Karger AG. en_US
dc.language.iso en en_US
dc.relation.ispartof Cardiology en_US
dc.rights info:eu-repo/semantics/closedAccess en_US
dc.subject Coronary slow-flow en_US
dc.subject Endothelial function en_US
dc.subject Homocysteine en_US
dc.subject Oxidative stress en_US
dc.subject biological marker en_US
dc.subject glutathione en_US
dc.subject homocysteine en_US
dc.subject lipid en_US
dc.subject malonaldehyde en_US
dc.subject superoxide dismutase en_US
dc.subject adult en_US
dc.subject amino acid blood level en_US
dc.subject angiocardiography en_US
dc.subject article en_US
dc.subject blood sampling en_US
dc.subject brachial artery en_US
dc.subject cell function en_US
dc.subject controlled study en_US
dc.subject coronary artery blood flow en_US
dc.subject coronary artery dilatation en_US
dc.subject coronary artery disease en_US
dc.subject coronary risk en_US
dc.subject coronary slow flow en_US
dc.subject correlation analysis en_US
dc.subject endothelium en_US
dc.subject endothelium cell en_US
dc.subject female en_US
dc.subject heart infarction en_US
dc.subject human en_US
dc.subject lipid peroxidation en_US
dc.subject major clinical study en_US
dc.subject male en_US
dc.subject oxidative stress en_US
dc.subject pathogenesis en_US
dc.subject priority journal en_US
dc.subject risk assessment en_US
dc.subject statistical significance en_US
dc.subject ultrasound en_US
dc.subject Adult en_US
dc.subject Aged en_US
dc.subject Blood Flow Velocity en_US
dc.subject Coronary Arteriosclerosis en_US
dc.subject Coronary Circulation en_US
dc.subject Endothelium, Vascular en_US
dc.subject Female en_US
dc.subject Humans en_US
dc.subject Male en_US
dc.subject Middle Aged en_US
dc.subject Oxidative Stress en_US
dc.title Effect of homocysteine-induced oxidative stress on endothelial function in coronary slow-flow en_US
dc.type Article en_US
dc.identifier.volume 107 en_US
dc.identifier.issue 4 en_US
dc.identifier.startpage 313
dc.identifier.startpage 313 en_US
dc.identifier.endpage 320 en_US
dc.authorid 0000-0001-5080-3192
dc.authorid 0000-0002-0705-7726
dc.identifier.doi 10.1159/000099068
dc.relation.publicationcategory Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı en_US
dc.identifier.pmid 17264512 en_US
dc.identifier.scopus 2-s2.0-34249027029 en_US
dc.identifier.wos WOS:000206881800006 en_US

Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record