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Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity

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dc.contributor.author Özkur, E.
dc.contributor.author Karadağ, A.S.
dc.contributor.author Üstüner, P.
dc.contributor.author Aksoy, B.
dc.contributor.author Eşme, P.
dc.contributor.author Çalışkan, E.
dc.contributor.author Akoğlu, G.
dc.contributor.author Kalkan, G.
dc.contributor.author Demirseren, D.D.
dc.contributor.author Polat, M.
dc.contributor.author Ozden, M.G.
dc.contributor.author Kılınç, F.
dc.contributor.author Yalçınkaya İyidal, A.
dc.contributor.author Kıvanç Altunay, İ.
dc.contributor.author Türkmen, M.
dc.contributor.author Uğurer, E.
dc.contributor.author Baysak, S.
dc.contributor.author Fettahlıoğlu Karaman, B.
dc.contributor.author Mammadlı, K.
dc.contributor.author Baykal Selçuk, L.
dc.contributor.author Türkoğlu, Z.
dc.contributor.author Atcı, T.
dc.contributor.author Didar Balcı, D.
dc.contributor.author Adışen, E.
dc.contributor.author Temel, B.
dc.contributor.author Aktan, Ş.
dc.contributor.author Kaçar, Nida
dc.contributor.author Gündüz, K.
dc.contributor.author Türel Ertmertcan, A.
dc.contributor.author Özdemir, M.
dc.contributor.author Ünal Çakıter, A.
dc.contributor.author Çölgeçen, E.
dc.contributor.author Uçmak, D.
dc.contributor.author Kelekçi, H.
dc.contributor.author Ataseven, A.
dc.contributor.author Durmaz, K.
dc.contributor.author Kaya Özden, H.
dc.contributor.author Engin, B.
dc.contributor.author Yazıcı, S.
dc.contributor.author Alpsoy, E.
dc.date.accessioned 2021-02-02T09:27:08Z
dc.date.available 2021-02-02T09:27:08Z
dc.date.issued 2020
dc.identifier.issn 03076938 (ISSN)
dc.identifier.uri http://hdl.handle.net/11499/37568
dc.description.abstract Background: Hidradenitis suppurativa (HS) is a chronic, relapsing and debilitating inflammatory disease associated with profound morbidity. Aim: In this multicentre study, we investigated the demographic and clinical features of HS, and determined risk factors of disease severity. Methods: In total, 1221 patients diagnosed with HS from 29 centres were enrolled, and the medical records of each patient were reviewed. Results: The mean age of disease onset was 26.2 ± 10.4 years, and almost 70% (n = 849) of patients were current or former smokers. Mean disease duration was 8.9 ± 8.4 years with a delay in diagnosis of 5.8 ± 3.91 years. Just over a fifth (21%; n = 256) of patients had a family history of HS. The axillary, genital and neck regions were more frequently affected in men than in women, and the inframammary region was more frequently affected in women than in men (P < 0.05 for all). Acne (40.8%), pilonidal sinus (23.6%) and diabetes mellitus (12.6%) were the most prevalent associated diseases. Of the various therapies used, antibiotics (76.4%) were most common followed by retinoids (41.7%), surgical interventions (32.0%) and biologic agents (15.4%). Logistic regression analysis revealed that the most important determinants of disease severity were male sex (OR = 2.21) and involvement of the genitals (OR = 3.39) and inguinal region (OR = 2.25). More severe disease was associated with comorbidity, longer disease duration, longer diagnosis delay and a higher number of smoking pack-years. Conclusions: Our nationwide cohort study found demographic and clinical variation in HS, which may help broaden the understanding of HS and factors associated with disease severity. © 2020 British Association of Dermatologists
dc.language.iso English
dc.publisher Blackwell Publishing Ltd
dc.relation.isversionof 10.1111/ced.14478
dc.rights info:eu-repo/semantics/closedAccess
dc.title Clinical and demographic features of hidradenitis suppurativa: a multicentre study of 1221 patients with an analysis of risk factors associated with disease severity
dc.type Article
dc.relation.journal Clinical and Experimental Dermatology
dc.contributor.authorID 0000-0001-8730-8056
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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