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Assessment of novel biomarkers: STREM-1, pentraxin-3 and pro-adrenomedullin in the early diagnosis of neonatal early onset sepsis

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dc.contributor.author Tunç, T.
dc.contributor.author Polat, A.
dc.contributor.author Özdemir, R.
dc.contributor.author Kiliçaslan, B.
dc.contributor.author Can, E.
dc.contributor.author Çelik, H.T.
dc.contributor.author Arsan, S.
dc.contributor.author Kader, S.
dc.contributor.author Erol, S.
dc.contributor.author Uslu, S.
dc.contributor.author Özdemir, Özmert Muhammet Ali
dc.contributor.author Özcan, B.
dc.contributor.author Hanta, D.
dc.contributor.author Dilli, D.
dc.contributor.author Narter, F.
dc.contributor.author Gültekin, N.
dc.contributor.author Güzoǧlu, N.
dc.contributor.author Aydemir, Ö.
dc.date.accessioned 2021-02-02T09:27:06Z
dc.date.available 2021-02-02T09:27:06Z
dc.date.issued 2020
dc.identifier.issn 19345798 (ISSN)
dc.identifier.uri http://hdl.handle.net/11499/37565
dc.description.abstract BACKGROUND: Early onset bacterial sepsis in neonates (EOS) is recognized as an important health condition. Early diagnosis is crucial. However, blood culture results are released in 48-72 hours. Many biomarkers have been investigated but none have been accepted as the gold standard. This study aimed to investigate the diagnostic value of the molecules: soluble form of triggering receptor expressed on myeloid cells-1 (sTREM-1), pentraxin-3 (PTX-3) and pro adrenomedullin (pro-ADM) in EOS and compare with currently used biomarkers. METHODS: In this multicenter prospective study, patients were enrolled from different NICUs around the Turkey. Patient data were collected via web-based registry system from attending centers. Neonates, hospitalized with a suspicion of EOS were enrolled. Blood culture and routine blood tests were collected and a serum sample was obtained and kept in-80°C for studying the molecules. According to laboratory results, patients were divided into three groups as; proven sepsis, clinical sepsis and control group. Groups were compared in terms of demographic, clinical and laboratory findings. The primary outcome of the study was to assess any difference between groups in terms of the diagnostic value of the markers aforementioned. RESULTS: A total of 130 patients were enrolled; proven sepsis (n = 36), clinical sepsis (n = 53) and control (n = 41) groups. Groups were similar in terms of demographic findings; mean WBC (P = 0.445), procalcitonin (PCT) (P = 0.083) and IL-6 (P = 0.814) levels. Mean C-reactive protein (CRP) level was significantly higher in clinical sepsis and proven sepsis groups compared to control group (P < 0.001). Mean PTX-3 (P = 0.547), pro-ADM (P = 0.766) and sTREM-1 (P = 0.838) levels were similar between groups. CONCLUSION: These promising molecules failed to help in early diagnosis of EOS. Their relation to correlation with disease progression may make more sense as they seem to be expressed in higher amounts with the progression of the disease in previous studies. CRP was the most frequently used biomarker for detecting the sepsis in our study population. © 2020-IOS Press and the authors. All rights reserved.
dc.language.iso English
dc.publisher IOS Press
dc.relation.isversionof 10.3233/NPM-180131
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Biomarker
dc.subject neonatal early onset sepsis
dc.subject pentraxin-3
dc.subject pro-ADM
dc.subject sTREM-1
dc.subject C reactive protein
dc.subject interleukin 6
dc.subject pentraxin 3
dc.subject proadrenomedullin
dc.subject procalcitonin
dc.subject triggering receptor expressed on myeloid cells 1
dc.subject Article
dc.subject blood culture
dc.subject clinical practice
dc.subject controlled study
dc.subject diagnostic value
dc.subject early diagnosis
dc.subject female
dc.subject human
dc.subject leukocyte
dc.subject major clinical study
dc.subject male
dc.subject newborn
dc.subject newborn sepsis
dc.subject priority journal
dc.subject prospective study
dc.subject Turkey (republic)
dc.title Assessment of novel biomarkers: STREM-1, pentraxin-3 and pro-adrenomedullin in the early diagnosis of neonatal early onset sepsis
dc.type Article
dc.relation.journal Journal of Neonatal-Perinatal Medicine
dc.contributor.authorID 0000-0002-2499-4949
dc.identifier.volume 13
dc.identifier.issue 1
dc.identifier.startpage 39
dc.identifier.endpage 45
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index PubMed

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