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Quantitative computed tomography assessment for systemic sclerosis–related interstitial lung disease: comparison of different methods

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dc.contributor.author Ufuk, Furkan
dc.contributor.author Demirci, Mahmut
dc.contributor.author Altınışık, Göksel
dc.date.accessioned 2021-02-02T09:23:42Z
dc.date.available 2021-02-02T09:23:42Z
dc.date.issued 2020
dc.identifier.issn 09387994 (ISSN)
dc.identifier.uri http://hdl.handle.net/11499/37038
dc.description.abstract Objectives: To compare the previously defined six different histogram-based quantitative lung assessment (QLA) methods on high-resolution CT (HRCT) in patients with systemic sclerosis (SSc)–related interstitial lung disease (ILD). Methods: The HRCT images of SSc patients with ILD were reviewed, and the visual ILD score (semiquantitative) and the severity of ILD (limited or extensive) were calculated. The QLA score of ILD was evaluated using the previously defined six different methods and parameters (different lung attenuation ranges, skewness, kurtosis, mean lung attenuation, and standard deviation [SD]). Pulmonary function tests (PFTs) were also performed on all patients. Relationships among variables were evaluated using Spearman’s correlation coefficient (r). Diagnostic performance of quantitative methods for the ability to differentiate the limited from extensive ILD was calculated using ROC analysis. Results: Fifty-five patients were included in the study. There was a significant correlation between all quantitative and semiquantitative measurement results (p < 0.0001). The QLA scores revealed a significant correlation with PFT results. The kurtosis value of the voxels between − 200 and − 1024 Hounsfield unit (HU) (Method-5) showed the best correlation with semiquantitative evaluation (r = − 0.740, p < 0.0001). The ROC analysis demonstrated the best performance of SD of the voxels between − 400 and − 950 HU (Method-6) for histogram analysis method and Method-3 (voxels between − 260 and − 600 HU were calculated as ILD) for CT density cutoff methods. Conclusions: All the QLA methods are applicable in assessing the ILD score in SSc patients and have potential importance to differentiate limited from extensive ILD. Key Points: • Quantitative interstitial lung disease assessment helps clinicians to assess systemic sclerosis patients with interstitial lung disease. • Quantitative lung assessment methods are applicable in assessing the interstitial lung disease score in systemic sclerosis patients. • Quantitative lung assessment methods have potential importance in the management of patients. © 2020, European Society of Radiology.
dc.language.iso English
dc.publisher Springer
dc.relation.isversionof 10.1007/s00330-020-06772-2
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Interstitial lung diseases
dc.subject Multidetector computed tomography
dc.subject Pulmonary function tests
dc.subject Quantitative evaluation
dc.subject Systemic sclerosis
dc.subject adult
dc.subject Article
dc.subject comparative study
dc.subject correlation coefficient
dc.subject digital imaging and communications in medicine
dc.subject disease severity
dc.subject female
dc.subject forced expiratory volume
dc.subject forced vital capacity
dc.subject high resolution computer tomography
dc.subject histogram
dc.subject human
dc.subject image analysis
dc.subject interstitial lung disease
dc.subject lung function test
dc.subject major clinical study
dc.subject male
dc.subject multidetector computed tomography
dc.subject priority journal
dc.subject quantitative analysis
dc.subject receiver operating characteristic
dc.subject retrospective study
dc.subject systemic sclerosis
dc.subject total lung capacity
dc.subject aged
dc.subject complication
dc.subject diagnostic imaging
dc.subject lung
dc.subject middle aged
dc.subject pathophysiology
dc.subject procedures
dc.subject severity of illness index
dc.subject very elderly
dc.subject vital capacity
dc.subject x-ray computed tomography
dc.subject Adult
dc.subject Aged
dc.subject Aged, 80 and over
dc.subject Female
dc.subject Forced Expiratory Volume
dc.subject Humans
dc.subject Lung
dc.subject Lung Diseases, Interstitial
dc.subject Male
dc.subject Middle Aged
dc.subject Multidetector Computed Tomography
dc.subject Respiratory Function Tests
dc.subject ROC Curve
dc.subject Scleroderma, Systemic
dc.subject Severity of Illness Index
dc.subject Tomography, X-Ray Computed
dc.subject Vital Capacity
dc.title Quantitative computed tomography assessment for systemic sclerosis–related interstitial lung disease: comparison of different methods
dc.type Article
dc.relation.journal European Radiology
dc.contributor.authorID 0000-0002-8614-5387
dc.contributor.authorID 0000-0001-8201-9618
dc.identifier.volume 30
dc.identifier.issue 8
dc.identifier.startpage 4369
dc.identifier.endpage 4380
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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