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Retrospective comparison of efficacy and safety of CAPOX and FOLFOX regimens as adjuvant treatment in patients with stage III colon cancer

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dc.contributor.author Degirmencioğlu, Serkan
dc.contributor.author Tanrıverdi, O.
dc.contributor.author Demiray, Atike Gökçen
dc.contributor.author Şenol, Hande
dc.contributor.author Gököz Doğu, Gamze
dc.contributor.author Yaren, Arzu
dc.date.accessioned 2020-06-08T12:11:28Z
dc.date.available 2020-06-08T12:11:28Z
dc.date.issued 2019
dc.identifier.issn 03000605 (ISSN)
dc.identifier.uri http://hdl.handle.net/11499/30154
dc.description.abstract Objective: This study aimed to evaluate the efficacy and safety profile of capecitabine and oxaliplatin (CAPOX) and 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) regimens as adjuvant treatment in patients with stage III colon cancer. Methods: A total of 243 patients who received CAPOX and FOLFOX chemotherapy between 2014 and 2018 for stage III colon cancer in two centers were retrospectively studied. Among the patients, 106 (43.6%) and 137 (56.4%) were treated using CAPOX and FOLFOX regimens, respectively. Efficacy, treatment-related side effects, and overall survival rates with these two regimens were compared. Results: The rate of disease progression was significantly higher in the presence of moderately/poorly differentiated histology, and KRAS and NRAS mutations. An increased number of metastatic lymph nodes and prolonged time from surgery to chemotherapy significantly increased disease progression. Patients who received CAPOX were significantly older than those who received FOLFOX. Disease progression, metastasis, and mortality rates were significantly higher in the FOLFOX arm than in the CAPOX arm. There was no significant difference in the overall survival rate between the two regimens. Conclusion: The CAPOX regimen is preferred in older patients. Disease progression, metastasis, and mortality rates are higher with FOLFOX than with CAPOX. © The Author(s) 2019.
dc.language.iso English
dc.publisher SAGE Publications Ltd
dc.relation.isversionof 10.1177/0300060519848258
dc.rights info:eu-repo/semantics/openAccess
dc.subject CAPOX
dc.subject Colon carcinoma
dc.subject FOLFOX
dc.subject mortality
dc.subject overall survival
dc.subject toxicity
dc.subject capecitabine
dc.subject fluorouracil
dc.subject folinic acid
dc.subject oxaliplatin
dc.subject antineoplastic agent
dc.subject adult
dc.subject age
dc.subject aged
dc.subject anemia
dc.subject Article
dc.subject cancer adjuvant therapy
dc.subject cancer growth
dc.subject cancer staging
dc.subject colon cancer
dc.subject comparative study
dc.subject diarrhea
dc.subject drug efficacy
dc.subject drug safety
dc.subject female
dc.subject gene mutation
dc.subject hand foot syndrome
dc.subject histopathology
dc.subject human
dc.subject liver toxicity
dc.subject lymph node metastasis
dc.subject major clinical study
dc.subject male
dc.subject mortality rate
dc.subject neuropathy
dc.subject neutropenia
dc.subject oncogene K ras
dc.subject oncogene N ras
dc.subject retrospective study
dc.subject therapy delay
dc.subject thrombocytopenia
dc.subject clinical trial
dc.subject colon tumor
dc.subject follow up
dc.subject middle aged
dc.subject multicenter study
dc.subject pathology
dc.subject prognosis
dc.subject survival rate
dc.subject Adult
dc.subject Aged
dc.subject Antineoplastic Combined Chemotherapy Protocols
dc.subject Capecitabine
dc.subject Colonic Neoplasms
dc.subject Female
dc.subject Fluorouracil
dc.subject Follow-Up Studies
dc.subject Humans
dc.subject Leucovorin
dc.subject Lymphatic Metastasis
dc.subject Male
dc.subject Middle Aged
dc.subject Neoplasm Staging
dc.subject Oxaliplatin
dc.subject Prognosis
dc.subject Retrospective Studies
dc.subject Survival Rate
dc.title Retrospective comparison of efficacy and safety of CAPOX and FOLFOX regimens as adjuvant treatment in patients with stage III colon cancer
dc.type Article
dc.contributor.authorID 0000-0002-1213-2778
dc.contributor.authorID 0000-0003-4397-5468
dc.contributor.authorID 0000-0001-8142-0362
dc.identifier.volume 47
dc.identifier.issue 6
dc.identifier.startpage 2507
dc.identifier.endpage 2515
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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