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Treatment of severe keratoconus hydrops with intracameral platelet-rich plasma injection

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dc.contributor.author Alio, J.L.
dc.contributor.author Toprak, İbrahim
dc.contributor.author Rodriguez, A.E.
dc.date.accessioned 2020-06-08T12:10:52Z
dc.date.available 2020-06-08T12:10:52Z
dc.date.issued 2019
dc.identifier.issn 02773740 (ISSN)
dc.identifier.uri http://hdl.handle.net/11499/29997
dc.description.abstract Purpose: To present successful management of severe corneal hydrops by corneal optical coherence tomography (OCT) guidance and intracameral application of eye platelet-rich plasma (E-PRP) in a case with Down syndrome. Methods: A 36-year-old woman with Down syndrome presented with acute vision loss, pain, photophobia, and corneal edema in the left eye. Clinical examination revealed keratoconus in the right eye and extreme keratoconus with severe corneal hydrops in the left eye. Anterior segment OCT (MS-39, Costruzione Strumenti Oftalmici, Firenze, Italy) showed intrastromal cystic fluid collection and ruptured and detached Descemet membrane. The OCT-guided management of hydrops is first described in this case report. Results: Medical treatment and intracameral sulfur hexafluoride injection failed. A sterile 0.3 mL of E-PRP was injected into the anterior chamber. Clinical and anatomical improvement began from the first postoperative day, and corneal edema totally resolved at 1 week. Postoperatively, no significant side effect was noted except an early transient moderate (28 mm Hg) intraocular pressure peak. Anterior segment-OCT demonstrated dramatic normalization in corneal morphology with total disappearance of fluid in the cystic intracorneal space, closure of the DM rupture, and DM reattachment. The patient was stable during the 6-month follow-up.Conclusions:In this case, intraocular E-PRP was a promising, apparently safe, and effective treatment option in management of corneal hydrops, in which conventional approaches failed. This is the first case in the literature to describe OCT appearance of corneal hydrops and intracameral use of E-PRP for the resolution of DM rupture in acute corneal hydrops. © 2019 Wolters Kluwer Health, Inc. All rights reserved.
dc.language.iso English
dc.publisher Lippincott Williams and Wilkins
dc.relation.isversionof 10.1097/ICO.0000000000002070
dc.rights info:eu-repo/semantics/closedAccess
dc.subject corneal surgery
dc.subject corneal transplantation
dc.subject Down syndrome
dc.subject keratoconus
dc.subject platelet-rich plasma
dc.subject sulfur hexafluoride
dc.subject adult
dc.subject Article
dc.subject case report
dc.subject clinical article
dc.subject clinical examination
dc.subject controlled study
dc.subject cornea edema
dc.subject cornea transplantation
dc.subject corrected distance visual acuity
dc.subject disease severity
dc.subject eye pain
dc.subject female
dc.subject follow up
dc.subject human
dc.subject intraocular pressure
dc.subject keratometry
dc.subject optical coherence tomography
dc.subject photophobia
dc.subject postoperative period
dc.subject priority journal
dc.subject slit lamp microscopy
dc.subject thrombocyte rich plasma
dc.subject treatment failure
dc.subject visual impairment
dc.subject anterior eye chamber
dc.subject complication
dc.subject diagnostic imaging
dc.subject drug effect
dc.subject intraocular drug administration
dc.subject treatment outcome
dc.subject visual acuity
dc.subject Adult
dc.subject Anterior Chamber
dc.subject Corneal Edema
dc.subject Down Syndrome
dc.subject Female
dc.subject Humans
dc.subject Injections, Intraocular
dc.subject Intraocular Pressure
dc.subject Keratoconus
dc.subject Platelet-Rich Plasma
dc.subject Tomography, Optical Coherence
dc.subject Treatment Outcome
dc.subject Visual Acuity
dc.title Treatment of severe keratoconus hydrops with intracameral platelet-rich plasma injection
dc.type Article
dc.identifier.volume 38
dc.identifier.issue 12
dc.identifier.startpage 1595
dc.identifier.endpage 1598
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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