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P-glycoprotein polymorphism in hypo- and hyper-thyroidism patients

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dc.contributor.author Turgut, G
dc.contributor.author Bastemir, M
dc.contributor.author Turgut, S
dc.contributor.author Akin, F
dc.contributor.author Kursunluoglu, R
dc.contributor.author Kaptanoglu, B
dc.date.accessioned 2019-08-19T13:25:00Z
dc.date.available 2019-08-19T13:25:00Z
dc.date.issued 2008
dc.identifier.issn 0301-4851
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/19150
dc.description.abstract P-glycoprotein (Pgp) is encoded by the multidrug resistance gene (MDR1) in humans and is the product of MDR1. It is expressed in various tissues and is related to drug distribution in intestinal erythrocytes, capillary endotel of brain, proximal tubules cells of kidneys and liver canalicular cells. Expression of Pgp is affected by Pgp polymorphism, and exon 26 C3435T polymorphism is the most common one. It has been thought that expression of Pgp is high in C-allele subjects and this situation is responsible for the resistance against some drugs and substances. Pgp may have a role in the distribution of thyroid hormones, drugs used for hypo- and hyperthyroidism and the resistance occurred. For this purpose possible relationship between T and C alleles and frequency of Pgp polymorphism as well as thyroid hormone distribution in patients with hypo- and hyperthyroidism was investigated. Thirty five hyperthyroidism patients diagnosed as Graves' disease, 78 hypothyroidism patients diagnosed as Hashimoto's thyroiditis and 100 healthy volunteers were included in the study. According to the results obtained no statistically significant difference was found in Pgp C3435T polymorphism between hypo- and hyperthyroidism patients. In addition, the serum free T3 levels of hyperthyroidism patients with C alleles was higher than those of subjects with T alleles. No statistically significant difference was seen in the CC, CT and TT genotype frequencies between the patients and control groups. In conclusion, it seems that Pgp polymorphism is not a predictor factor for the occurrence of hypo- and hyperthyroidism. There is a significant relationship between Pgp and the elevated serum free T3 levels of hyperthyroidism patients, and further research will help understand this situation.
dc.language.iso English
dc.publisher SPRINGER
dc.relation.isversionof 10.1007/s11033-007-9142-y
dc.subject P-glycoprotein polymorphism; MDR1; C3435T; Hyperthyroidism;
dc.subject Hypothyroidism
dc.title P-glycoprotein polymorphism in hypo- and hyper-thyroidism patients
dc.type Article
dc.identifier.volume 35
dc.identifier.issue 4
dc.identifier.startpage 693
dc.identifier.endpage 698
dc.identifier.index WOS

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