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Insertion/Deletion polymorphism of the angiotensin I-converting enzyme

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dc.contributor.author Yaren, A
dc.contributor.author Turgut, S
dc.contributor.author Kursunluoglu, R
dc.contributor.author Oztop, I
dc.contributor.author Turgut, G
dc.contributor.author Degirmencioglu, S
dc.contributor.author Kelten, C
dc.contributor.author Erdem, E
dc.date.accessioned 2019-08-19T12:48:22Z
dc.date.available 2019-08-19T12:48:22Z
dc.date.issued 2007
dc.identifier.issn 1081-5589
dc.identifier.issn J9 J INVEST MED
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/18932
dc.description.abstract The aims of the present study were to investigate the distribution of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene in breast cancer patients and the association between ACE genotypes and clinicopathologic features, as well as their effects on prognosis. We assessed the I/D polymophism of the ACE gene by using polymerase chain reaction from peripheral blood in breast cancer and healthy age-matched women. The clinicopathologic parameters of breast cancer patients were obtained from medical records. Of the 57 patients, 31 (54.4%) had DID, 24 (42.1%) had ID, and 2 (3.5%) had II genotypes. In control subjects, 33 (63.5%) had DD, 12 (23.1%) had ID, and 7 (13.4%) had II genotypes. The ID genotype was seen more commonly in breast cancer patients (p =.03). When the combination of ID and II genotypes was used as a reference group, the DD genotype was associated with negative hormone receptor status (p = .003), tumor size (p = .054), and lymph node involvement (p = .07) but not histologic high grade and c-erb B2 overexpression. These results suggest that the DID genotype may accompany poor prognostic factors and influence the tumor course.
dc.language.iso English
dc.publisher B C DECKER INC
dc.relation.isversionof 10.2310/6650.2007.00006
dc.subject angiotensin-converting enzyyme gene polymorphism; breast cancer;
dc.subject prognostic factors
dc.title Insertion/Deletion polymorphism of the angiotensin I-converting enzyme
dc.title gene in patients with breast cancer and effects on prognostic factors
dc.type Article
dc.relation.journal JOURNAL OF INVESTIGATIVE MEDICINE
dc.identifier.volume 55
dc.identifier.issue 5
dc.identifier.startpage 255
dc.identifier.endpage 261
dc.identifier.index WOS


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