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Quantitative assessment of macular contraction and vitreoretinal interface alterations in diabetic macular edema treated with intravitreal anti-VEGF injections

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dc.contributor.author Çetin, Ebru Nevin
dc.contributor.author Demirtaş, Önder
dc.contributor.author Özbakış, N.C.
dc.contributor.author Pekel, Gökhan
dc.date.accessioned 2019-08-16T13:32:12Z
dc.date.available 2019-08-16T13:32:12Z
dc.date.issued 2018
dc.identifier.issn 0721832X (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/10646
dc.description.abstract Background: Macular contraction after anti-vascular endothelial growth factor (anti-VEGF) injections for diabetic macular edema (DME) was evaluated by documenting the displacement of macular capillary vessels and epiretinal membrane (ERM) formation. Methods: A total of 130 eyes were included in this retrospective study. The study group consisted of 63 eyes which had intravitreal anti-VEGF injections for DME, and the control group included 67 eyes without central DME. The study and the control groups were well balanced in terms of diabetes duration and HbA1c. The distances between the bifurcation of the macular capillary retinal vessels were measured, and ERM status was evaluated based on spectral-OCT findings on the initial and final visit. Results: In the study group, the mean number of injections was 4.7 ± 2.6 (3–14). The mean follow-up time was 16.7 ± 7.8 months in the study group whereas it was 20.7 ± 10.9 months in the control group (p = 0.132). The change in distance measurements between the reference points on macular capillary vessels was significant in all lines except line c (p < 0.05 for lines a, b, d, e, and f) in the study group whereas it was significant in only line e in the control group (p = 0.007, paired samples test). However, when the change in macular thickness was accounted as a confounding factor, the change in distances between the references points from the initial visit to the final visit lost its significance (repeated measures ANCOVA, p > 0.05). During follow-up, the number of cases with ERM changed from 10 to 12 in the study group whereas it remained three in the control group. Conclusion: There was a displacement of macular capillary vessels which was associated with the change in macular thickness in eyes having anti-VEGF injections for DME. The number of ERM cases did not change significantly during the follow-up. © 2018, Springer-Verlag GmbH Germany, part of Springer Nature.
dc.language.iso English
dc.publisher Springer Verlag
dc.relation.isversionof 10.1007/s00417-018-4042-5
dc.rights info:eu-repo/semantics/closedAccess
dc.subject Anti-VEGF
dc.subject Diabetic macular edema
dc.subject Epiretinal membrane
dc.subject Macular contraction
dc.subject Macular vessel displacement
dc.subject Vitreoretinal interface
dc.subject aflibercept
dc.subject hemoglobin A1c
dc.subject ranibizumab
dc.subject angiogenesis inhibitor
dc.subject bevacizumab
dc.subject vasculotropin A
dc.subject adult
dc.subject Article
dc.subject best corrected visual acuity
dc.subject central macular thickness
dc.subject clinical article
dc.subject controlled study
dc.subject diabetic macular edema
dc.subject diabetic patient
dc.subject disease duration
dc.subject female
dc.subject follow up
dc.subject human
dc.subject intraocular pressure
dc.subject male
dc.subject middle aged
dc.subject priority journal
dc.subject quantitative diagnosis
dc.subject retina
dc.subject retina capillary
dc.subject retrospective study
dc.subject spectral domain optical coherence tomography
dc.subject vitreoretinal interface
dc.subject vitreous body
dc.subject antagonists and inhibitors
dc.subject complication
dc.subject diabetic retinopathy
dc.subject intravitreal drug administration
dc.subject macular edema
dc.subject optical coherence tomography
dc.subject pathology
dc.subject retina blood vessel
dc.subject retina macula lutea
dc.subject treatment outcome
dc.subject visual acuity
dc.subject Angiogenesis Inhibitors
dc.subject Bevacizumab
dc.subject Diabetic Retinopathy
dc.subject Female
dc.subject Follow-Up Studies
dc.subject Humans
dc.subject Intravitreal Injections
dc.subject Macula Lutea
dc.subject Macular Edema
dc.subject Male
dc.subject Middle Aged
dc.subject Ranibizumab
dc.subject Retinal Vessels
dc.subject Retrospective Studies
dc.subject Tomography, Optical Coherence
dc.subject Treatment Outcome
dc.subject Vascular Endothelial Growth Factor A
dc.subject Visual Acuity
dc.subject Vitreous Body
dc.title Quantitative assessment of macular contraction and vitreoretinal interface alterations in diabetic macular edema treated with intravitreal anti-VEGF injections
dc.type Article
dc.relation.journal Graefe's Archive for Clinical and Experimental Ophthalmology
dc.identifier.volume 256
dc.identifier.issue 10
dc.identifier.startpage 1801
dc.identifier.endpage 1806
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed


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