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Impaired systolic blood pressure recovery and heart rate recovery after graded exercise in patients with metabolic syndrome

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dc.contributor.author Alihanoglu, Yusuf İzzettin
dc.contributor.author Yıldız,Bekir Serhad
dc.contributor.author Kılıç, İsmail Doğu
dc.contributor.author Uludağ, Burcu
dc.contributor.author Demirci, E.E.
dc.contributor.author Zungur, M.
dc.contributor.author Evrengul, Harun
dc.contributor.author Kaftan, Asuman Havane
dc.date.accessioned 2019-08-16T13:17:39Z
dc.date.available 2019-08-16T13:17:39Z
dc.date.issued 2015
dc.identifier.issn 00257974 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/10404
dc.description.abstract The aim of this study was to evaluate and compare systolic blood pressure recovery and heart rate recovery (HRR) values obtained at various time intervals after maximal graded exercise treadmill testing between patients with metabolic syndrome (MS) and the controls without MS. To our knowledge, this is the first study indicating systolic blood pressure recovery (SBPR) impairment and its relations to HRR and other variables in this group of patients.The study population included 110 patients with MS (67 men, 43 women; mean age: 46±9 years) and 110 control subjects who did not meet the criteria for MS (58 men, 52 women; mean age: 44±10 years). All patients were selected from nonobese, apparently healthy sedentary individuals who had the ability to perform maximum exercise testing. SBPR was assessed by calculating the ratio of systolic blood pressure (SBP) obtained in the third minute of the recovery period to either the peak-exercise SBP or the SBP in the first minute of the recovery period after graded exercise testing. HRR values were calculated by subtracting the HR at the first, second, third, fourth, and fifth minutes of the recovery period from the HR reached at peak exercise.There was no significant difference found between the 2 groups with respect to age and sex distribution. As expected, patients with MS had higher waist circumference, fasting plasma glucose and serum triglyceride, and lower high-density lipoprotein cholesterol compared with control subjects. All HRR values calculated in the first, second, third, fourth, and fifth minutes were significantly detected lower in the MS group compared with the control group (HRR 1st: 32±10 vs 36±11; P=0.009; HRR 2nd: 47±10 vs 51±11; P=0.02; HRR 3rd: 53±11 vs 58±12; P=0.001; HRR 4th: 57±11 vs 64±12; P<0.001; HRR 5th: 60±16 vs 69±15; P<0.001). In addition, calculated mean values for SBPR1 and SBPR2 were >1 in patients with MS (1.01±0.2 vs 0.91±0.1 and 1.01±0.1 vs 0.94±0.1) and these were statistically significant compared with the control group (P<0.001 and P=0.002, respectively). The existence of MS was found to be the only parameter that was independently and positively related to SBPR values in the study population.Our findings suggest that only the existence of MS itself, not the presence of any MS components, is independently associated with SBPRs. We are of the opinion that significantly impaired SBPR values, in addition to the decreased HRR values observed in this group of patients, such as those with MS, may especially help identify patients with potentially increased cardiovascular risk despite normal exercise stress testing findings. © 2015 Wolters Kluwer Health, Inc. All rights reserved.
dc.language.iso English
dc.publisher Lippincott Williams and Wilkins
dc.relation.isversionof 10.1097/MD.0000000000000428
dc.rights info:eu-repo/semantics/openAccess
dc.subject glucose
dc.subject high density lipoprotein cholesterol
dc.subject low density lipoprotein cholesterol
dc.subject triacylglycerol
dc.subject glucose blood level
dc.subject lipid
dc.subject adult
dc.subject Article
dc.subject body mass
dc.subject body weight
dc.subject cholesterol blood level
dc.subject comparative study
dc.subject controlled study
dc.subject exercise
dc.subject female
dc.subject heart rate
dc.subject human
dc.subject major clinical study
dc.subject male
dc.subject metabolic syndrome X
dc.subject priority journal
dc.subject systolic blood pressure
dc.subject time
dc.subject treadmill exercise
dc.subject triacylglycerol blood level
dc.subject waist circumference
dc.subject blood
dc.subject blood pressure
dc.subject convalescence
dc.subject exercise test
dc.subject exercise tolerance
dc.subject middle aged
dc.subject pathophysiology
dc.subject physiology
dc.subject predictive value
dc.subject procedures
dc.subject prospective study
dc.subject regression analysis
dc.subject risk factor
dc.subject Turkey
dc.subject Adult
dc.subject Blood Glucose
dc.subject Blood Pressure
dc.subject Body Mass Index
dc.subject Exercise Test
dc.subject Exercise Tolerance
dc.subject Female
dc.subject Heart Rate
dc.subject Humans
dc.subject Lipids
dc.subject Male
dc.subject Metabolic Syndrome X
dc.subject Middle Aged
dc.subject Predictive Value of Tests
dc.subject Prospective Studies
dc.subject Recovery of Function
dc.subject Regression Analysis
dc.subject Risk Factors
dc.subject Time Factors
dc.subject Waist Circumference
dc.title Impaired systolic blood pressure recovery and heart rate recovery after graded exercise in patients with metabolic syndrome
dc.type Article
dc.relation.journal Medicine (United States)
dc.identifier.volume 94
dc.identifier.issue 2
dc.identifier.startpage e428
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS

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