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Circulating adhesion molecules and arterial stiffness

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dc.contributor.author Kılıç, İsmail Doğu
dc.contributor.author Findikoglu, G.
dc.contributor.author Alihanoglu, Y.I.
dc.contributor.author Yildiz, B.S.
dc.contributor.author Uslu, S.
dc.contributor.author Rota, S.
dc.contributor.author Evrengul, H.
dc.date.accessioned 2019-08-16T13:17:10Z
dc.date.available 2019-08-16T13:17:10Z
dc.date.issued 2015
dc.identifier.issn 19951892 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/10382
dc.description.abstract Aim: VCAM-1 and ICAM-1 are two important members of the immunoglobulin gene superfamily of adhesion molecules, and their potential role as biomarkers of diagnosis, severity and prognosis of cardiovascular disease has been investigated in a number of clinical studies. The aim of the present study was to determine the relationship between circulating ICAM-1 and VCAM-1 levels and aortic stiffness in patients referred for echocardiographic examination. Methods: Aortic distensibility was determined by echocardiography using systolic and diastolic aortic diameters in 63 consecutive patients referred for echocardiography. Venous samples were collected in the morning after a 12-hour overnight fast, and serum concentrations of ICAM-1 and VCAM-1 were measured using commercial enzyme immunoassay kits. Results: Data of a total of 63 participants (mean age 55.6 ± 10.5 years, 31 male) were included in the study. Circulating levels of adhesion molecules were VCAM-1: 12.604 ± 3.904 ng/ml and ICAM-1: 45.417 ± 31.429 ng/ml. We were unable to demonstrate any correlation between indices of aortic stiffness and VCAM-1 and ICAM-1 levels. Conclusion: The role of soluble adhesion molecules in cardiovascular disease has not been fully established and clinical studies show inconsistent results. Our results indicate that levels of circulating adhesion molecules cannot be used as markers of aortic stiffness in patients.
dc.language.iso English
dc.publisher Clinics Cardive Publishing (PTY)Ltd
dc.relation.isversionof 10.5830/CVJA-2014-060
dc.rights info:eu-repo/semantics/openAccess
dc.subject Adhesion molecules
dc.subject Aortic stiffness
dc.subject ICAM-1
dc.subject VCAM-1
dc.subject intercellular adhesion molecule 1
dc.subject vascular cell adhesion molecule 1
dc.subject biological marker
dc.subject ICAM1 protein, human
dc.subject adult
dc.subject aorta
dc.subject arterial stiffness
dc.subject Article
dc.subject blood vessel diameter
dc.subject echocardiography
dc.subject enzyme linked immunosorbent assay
dc.subject female
dc.subject human
dc.subject major clinical study
dc.subject male
dc.subject middle aged
dc.subject aged
dc.subject blood
dc.subject Doppler echocardiography
dc.subject echography
dc.subject pathophysiology
dc.subject predictive value
dc.subject prognosis
dc.subject risk factor
dc.subject severity of illness index
dc.subject Vascular Diseases
dc.subject Aged
dc.subject Aorta
dc.subject Biomarkers
dc.subject Echocardiography, Doppler
dc.subject Enzyme-Linked Immunosorbent Assay
dc.subject Female
dc.subject Humans
dc.subject Intercellular Adhesion Molecule-1
dc.subject Male
dc.subject Middle Aged
dc.subject Predictive Value of Tests
dc.subject Prognosis
dc.subject Risk Factors
dc.subject Severity of Illness Index
dc.subject Vascular Cell Adhesion Molecule-1
dc.subject Vascular Stiffness
dc.title Circulating adhesion molecules and arterial stiffness
dc.type Article
dc.relation.journal Cardiovascular Journal of Africa
dc.identifier.volume 26
dc.identifier.issue 1
dc.identifier.startpage 21
dc.identifier.endpage 24
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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