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Insulin sensitivity indices: Fasting versus glucose-stimulated ýndices in pediatric non-alcoholic fatty liver disease

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dc.contributor.author Özhan, Bayram
dc.contributor.author Ersoy, B.
dc.contributor.author Kiremitci, S.
dc.contributor.author Ozkol, M.
dc.contributor.author Taneli, F.
dc.date.accessioned 2019-08-16T13:15:57Z
dc.date.available 2019-08-16T13:15:57Z
dc.date.issued 2015
dc.identifier.issn 11283602 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/10322
dc.description.abstract OBJECTIVE: We aimed to compare insulin sensitivity indices, fasting vs glucose stimulated, in children and adolescents with non-alcoholic fatty liver disease. PATIENTS AND METHODS: Two hundredeleven obese children with median age of 11.24 ± 2.65 years were evaluated. After initial clinical and anthropometric examination, B-mode ultrasonography (USG) was performed and all subjects underwent Oral Glucose Tolerance Test (OGTT). Quantitative insulin sensitivity check index (QUICKI), homeostatic model assessment for insulin resistance (Homa-IR), the insulinogenic index (IGI), the Matsuda index, and the oral glucose insulin sensitivity (OGIS) model were used to determine peripheral insulin sensitivity. RESULTS: 59.24% (68 boys, 57 girls) of obese children had NALFD. The prevalence of FLD in obese adolescents was significantly higher than in prepubertal children (65.8% vs. 51.5%). Fasting glucose, insulin, Homa-IR, QUICKI, and OGIS and Matsuda were significantly different between subjects with and without NALFD. Insulin and glucose indices were not found to be significantly different in the prepubertal group, whereas Homa-IR, QUICKI, Matsuda, and OGIS were significantly different in the pubertal group. Age, waist circumference, and OUICKI were found to be risk factors associated with the presence of NALFD in the logistic-regression analysis. CONCLUSIONS: Age, waist circumference, and OUICKI were found to be risk factors associated with NALFD. As the value of QUICKI decreases, the probability of having steatosis increases. Although OGTT results gave the information about the glucose tolerance of a subject, indices derived from OGTT were not found to be superior to the traditional surrogates such as Homa-IR or QUICKI.
dc.language.iso English
dc.publisher Verduci Editore
dc.rights info:eu-repo/semantics/openAccess
dc.subject Children
dc.subject Fatty liver
dc.subject Indices
dc.subject Insulin sensitivity
dc.subject Obesity
dc.subject Puberty
dc.subject alanine aminotransferase
dc.subject aspartate aminotransferase
dc.subject glucose
dc.subject insulin
dc.subject triacylglycerol
dc.subject glucose blood level
dc.subject adolescent
dc.subject age
dc.subject Article
dc.subject body height
dc.subject body mass
dc.subject body weight
dc.subject child
dc.subject childhood disease
dc.subject childhood obesity
dc.subject comparative study
dc.subject controlled study
dc.subject correlational study
dc.subject disorders of carbohydrate metabolism
dc.subject echography
dc.subject fatty liver
dc.subject female
dc.subject groups by age
dc.subject homeostatic model assessment for insulin resistance
dc.subject human
dc.subject insulin resistance
dc.subject insulin sensitivity
dc.subject insulin sensitivity index
dc.subject insulinogenic index
dc.subject major clinical study
dc.subject male
dc.subject Matsuda index
dc.subject metabolic parameters
dc.subject nonalcoholic fatty liver
dc.subject oral glucose insulin sensitivity model
dc.subject oral glucose tolerance test
dc.subject prevalence
dc.subject Quantitative Insulin Sensitivity Check Index
dc.subject risk factor
dc.subject school child
dc.subject waist circumference
dc.subject analysis
dc.subject blood
dc.subject diet restriction
dc.subject metabolism
dc.subject obesity
dc.subject Blood Glucose
dc.subject Child
dc.subject Fasting
dc.subject Female
dc.subject Glucose
dc.subject Humans
dc.subject Insulin
dc.subject Insulin Resistance
dc.subject Male
dc.subject Non-alcoholic Fatty Liver Disease
dc.subject Risk Factors
dc.title Insulin sensitivity indices: Fasting versus glucose-stimulated ýndices in pediatric non-alcoholic fatty liver disease
dc.type Article
dc.relation.journal European Review for Medical and Pharmacological Sciences
dc.identifier.volume 19
dc.identifier.issue 18
dc.identifier.startpage 3450
dc.identifier.endpage 3458
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS


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