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Relationship of apelin, procalcitonin, and fetuin-A concentrations with carotid intima-media thickness in acromegaly

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dc.contributor.author Topsakal, Senay
dc.contributor.author Akin, Fulya
dc.contributor.author Turgut, Sebahat
dc.contributor.author Yaylalı, Güzin Fidan
dc.contributor.author Herek, Duygu
dc.contributor.author Ayada, Ceylan
dc.date.accessioned 2019-08-16T13:14:30Z
dc.date.available 2019-08-16T13:14:30Z
dc.date.issued 2015
dc.identifier.issn 00045632 (ISSN)
dc.identifier.uri http://acikerisim.pau.edu.tr:8080/xmlui/handle/11499/10256
dc.description.abstract Background Acromegaly is characterized by excess growth hormone and insulin-like growth factor-1 concentrations. There is conflicting evidence as to whether acromegaly is associated with an increased risk of atherosclerosis. Apelin is an adipose tissue-derived peptide that may be associated with hyperinsulinemia. Fetuin-A is a hepatocyte produced plasma glycoprotein that has an important role as a calcification inhibitor. The aim of this study was to examine apelin, fetuin-A, and procalcitonin concentrations and to assess their relationship with carotid intima medial thickness (cIMT) in subjects with acromegaly.MethodsApelin, fetuin-A, and procalcitonin serum concentrations were measured in 37 (20 inactive and 17 active) subjects with acromegaly and 30 control subjects, along with carotid intima medial thickness. Results The concentrations of apelin, fetuin-A, and procalcitonin were increased in subjects with acromegaly. There were significant correlations between apelin, fetuin-A, and procalcitonin in subjects with acromegaly. Carotid intima medial thickness values were similar between control subjects and subjects with acromegaly. Conclusions Carotid intima medial thickness was not increased in subjects with acromegaly. It is possible that the increased apelin and fetuin-A concentrations observed play a protective role against the development of atherosclerosis in subjects with acromegaly. © The Author(s) 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.
dc.language.iso English
dc.publisher SAGE Publications Ltd
dc.relation.isversionof 10.1177/0004563214562431
dc.rights info:eu-repo/semantics/openAccess
dc.subject Acromegaly
dc.subject apelin
dc.subject carotid intima media thickness
dc.subject fetuin-A
dc.subject procalcitonin
dc.subject cholesterol
dc.subject creatinine
dc.subject fetuin A
dc.subject glucose
dc.subject growth hormone
dc.subject high density lipoprotein cholesterol
dc.subject insulin
dc.subject low density lipoprotein cholesterol
dc.subject somatomedin binding protein 3
dc.subject somatomedin C
dc.subject triacylglycerol
dc.subject APLN protein, human
dc.subject calcitonin
dc.subject protein precursor
dc.subject signal peptide
dc.subject acromegaly
dc.subject adult
dc.subject age
dc.subject arterial wall thickness
dc.subject Article
dc.subject body height
dc.subject body mass
dc.subject body weight
dc.subject cholesterol blood level
dc.subject clinical article
dc.subject concentration (parameters)
dc.subject controlled study
dc.subject creatinine blood level
dc.subject diastolic blood pressure
dc.subject female
dc.subject glucose blood level
dc.subject growth hormone blood level
dc.subject human
dc.subject insulin blood level
dc.subject male
dc.subject priority journal
dc.subject systolic blood pressure
dc.subject triacylglycerol blood level
dc.subject blood
dc.subject case control study
dc.subject comparative study
dc.subject middle aged
dc.subject Adult
dc.subject alpha-2-HS-Glycoprotein
dc.subject Calcitonin
dc.subject Carotid Intima-Media Thickness
dc.subject Case-Control Studies
dc.subject Female
dc.subject Humans
dc.subject Intercellular Signaling Peptides and Proteins
dc.subject Male
dc.subject Middle Aged
dc.subject Protein Precursors
dc.title Relationship of apelin, procalcitonin, and fetuin-A concentrations with carotid intima-media thickness in acromegaly
dc.type Article
dc.relation.journal Annals of Clinical Biochemistry
dc.identifier.volume 52
dc.identifier.issue 4
dc.identifier.startpage 456
dc.identifier.endpage 461
dc.relation.publicationCategory Uluslararası Hakemli Dergi
dc.identifier.index Scopus
dc.identifier.index WOS
dc.identifier.index PubMed

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